Psychotropics and Related Topics From
Sixteen Years of Peer-Review Articles

NOTE FOR READERS: While most pharmacologic agents are called out by name, some articles may be overviews of entire classes of agents. For example, under sections such as ANTIDEPRESSANTS (not specified), the reader would find the following article: Rational Antidepressant Selection: Applying Evidence-Based Medicine to Complex Real-World Patients.

Likewise, certain pharmacologic advances can be rationalized only in the context of the disease itself. Among drug categories, you will find ‘non specified’ sections on Epidemiology, Bipolar, and Sleep Disturbances, to name just a few. Rather than omit entire categories of research because they did not correspond to a strict listing of drug names, we chose to deviate in certain instances for the sake of completeness. We hope this does not contribute to any confusion.

All articles prefaced with the    logo are indexed on under Psychopharmacol Bull.
— Sincerely, The Editors


DISCLAIMER: Although every effort has been made to ensure that drug information is presented accurately in all Medworks’ publications, the ultimate responsibility rests with the prescribing physician. Neither the publisher, nor the authors can be held responsible for errors or for any consequences arising from the use of information contained herein. Readers are strongly urged to consult additional relevant primary literature. No claims or endorsements are made for any drug or compound currently under clinical investigation.

ADHD (Not Specified)

 – Persisting Psychosocial Impairments in Adults Being Treated with Medication for Attention Deficit/Hyperactivity Disorder

 – Unmet Medication Coverage Needs among Adults with Attention Deficit/Hyperactivity Disorder (ADHD)


 – Agomelatine for Depression in Schizophrenia: A Case-Series


 – The Speed of Onset of Action of Alprazolam-XR Compared to Alprazolam-CT in Panic Disorder


 – Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto’s Thyroiditis

Alternative Medicine

 – Determinants of Complementary and Alternative Medicine Use by Patients with Bipolar Disorder 

Ambulatory Pschiatry (Not Specified)

 – Collaborative Care in Ambulatory Psychiatry: Content Analysis of Consultations to a Psychiatric Pharmacist


 – Amisulpride for Clozapine Induced Sialorrhea


 – Citalopram Versus Amitriptyline in Elderly Depressed Patients with or without Mild Cognitive Dysfunction: A Danish Multicentre Trial in General Practice

Anticonvulsants (not specified)

 – Evidence-Based Mental Health Use of Anticonvulsants During Pregnancy

 – Pharmacokinetics of Mood Stabilizers and New Anticonvulsants 

Innovative Treatment Strategies With Anticonvulsants: A Focus On Bipolar Disorder 

Antidepressants (not specified)

 – Rational Antidepressant Selection: Applying Evidence-Based Medicine to Complex Real-World Patients

 – Comparing The Methods Used To Compare Antidepressants 

 – A Survey of Prescribing Preferences in the Treatment of Refractory Depression: Recent Trends 

Great Expectations In Stereochemistry: Focus On Antidepressants 

A Discussion On The Methodologies Used To Evaluate Antidepressants 

 –Impact Of A Student Pharmacist Driven Medication Reconciliation And Antidepressant Treatment History Project At A Depression Clinic: A Pilot Study

Antipsychotics (not specified)

 – Three-Year Naturalistic Study On Early Use Of Long-Acting Injectable Antipsychotics In First Episode Psychosis

 – Do Long-Acting Injectable Antipsychotics Prevent or Delay Hospital Readmission?

 – Lack of Efficacy of Antipsychotics on Premenstrual Psychosis: A Case Report

 – Antipsychotic Induced Symptomatic Hyperprolactinemia: Are Dopamine Agonists Safe? 

 – Metabolic Syndrome with Different Antipsychotics: A Multicentre Cross-Sectional Study 

 – The Revised Dopamine Hypothesis of Schizophrenia: Evidence from Pharmacological MRI Studies with Atypical Antipsychotic Medication 

 – Antipsychotic Medications and Sudden Cardiac Death 

 – Antipsychotic-Induced Hyperprolactinemia and Sexual Dysfunction 

 – Sexual Side Effects Associated With Conventional and Atypical Antipsychotics 

 – Therapeutic Drug Monitoring of Antipsychotics 

 –Combined Antipsychotics And Electroconvulsive Therapy In An Acutely Psychotic Patient With Treatment-Resistant Schizophrenia

 –Sex Differences In Antipsychotic Related Metabolic Functioning In Schizophrenia Spectrum Disorders

Arpiprazole Lauroxil

 – A Phase-1 Study Comparing Pharmacokinetic And Safety Profiles Of Three Different Dose Intervals Of Aripiprazole Lauroxil

 – Metabolic And Endocrine Profiles During 1-Year Treatment Of Outpatients With Schizophrenia With Aripiprazole Lauroxil


 – Atomoxetine Induced Hypothermia: A Case Report 


 – Criteria for Defining Symptomatic and Sustained Remission in Bipolar I Disorder: a Post-Hoc Analysis of a 26-Week Aripiprazole Study (Study CN138-010) 

 – An Open-Label Assessment of Aripiprazole in the Treatment of PTSD 

 – Efficacy of High-Dose Aripiprazole for Treatment-Resistant Schizoaffective Disorder: A Case Report

 – Prospective Study to Evaluate the Efficacy of Aripiprazole as a Monotherapy in Patients with Severe Chronic Posttraumatic Stress Disorder: An Open Trial 

 -Aripiprazole-Induced Asymptomatic Hypertension: A Case Report


 – An Open Label Pilot Study Of Adjunctive Asenapine For The Treatment Of Posttraumatic Stress Disorder

 – Asenapine in the Treatment of Negative Symptoms of Schizophrenia: Clinical Trial Design and Rationale

Atypical Antipsychotics (not specified)

 – The Utilization of Atypical Antipsychotics in the Pain Medicine Physician’s Armamentarium

 – Atypical Antipsychotic Drugs and Diabetes Mellitus in the US Food and Drug Administration Adverse Event Database: A Systematic Bayesian Signal Detection Analysis 

 – Off-Label Second Generation Antipsychotics for Impulse Regulation Disorders: A Review 

 – Predicting Antipsychotic Use in Children 

 – Drug–Drug Interactions Associated with Second-Generation Antipsychotics: Considerations for Clinicians and Patients

 – Atypical Antipsychotics and Pituitary Neoplasms in the WHO Database 

 – Mood Stabilizers and Atypical Antipsychotics: Bimodal Treatments for Bipolar Disorder 

 – Drug Development for Anxiety Disorders: New Roles for Atypical Antipsychotics 

 – Advancing the Treatment of Anxiety Disorders: New Findings and Novel Uses for Atypical Antipsychotics

 – Disturbed Glucose Metabolism Among Patients Taking Olanzapine and Typical Antipsychotics 

 – Sexual Side Effects Associated With Conventional and Atypical Antipsychotics

Human And Economic Costs Of Schizophrenia: A Case Study Of The Impact Of Newer Antipsychotics 

Autism Spectrum Disorder(s) (not specified)

 – The Use of Complementery Alternative Medicine in Children and Adolescents with Autism Spectrum Disorder

 – Treatment Of Autism Spectrum Disorder In Children And Adolescents

 – Does Risperidone Improve Hyperacusia in Children with Autism? 

Benzodiazepines (not specified)

 – A Major Change of Prescribing Pattern in Absence of Adequate Evidence: Benzodiazepines Versus Newer Antidepressants in Anxiety Disorders

 – Pharmacokinetically Induced Benzodiazepine Withdrawal 

Bipolar Disorders (not specified)

 – Rating Scales And Safety Measurements In Bipolar Disorder And Schizophrenia – A Reference Guide

 – Rapid Cycling Bipolar Disorder and a Recent Substance Use Disorder: A 12-week, Double-Blind, Placebo-Controlled Pilot Study

 – Why Do Persons with Bipolar Disorder Stop Their Medication?

 – Bipolar-I Patient Characteristics Associated with Differences in Antimanic Medication Prescribing

 – Frequency of Stimulant Treatment and of Stimulant-Associated Mania/Hypomania in Bipolar Disorder Patients

 – Correlates of Functioning in Bipolar Disorder 

 – Bipolar-I Depression Outpatient Treatment Quality and Costs in Usual Care Practice 

 – Patterns of Pharmacotherapy and Treatment Response in Elderly Adults with Bipolar Disorder

 – Concordance with Treatment Guidelines for Bipolar Disorder: Data from the Systematic Treatment Enhancement Program for Bipolar Disorder 

 – Mood Stabilizers and Atypical Antipsychotics: Bimodal Treatments for Bipolar Disorder 

 – New Approaches to Modeling Bipolar Disorder 

 – Management of Bipolar Disorder in Children and Adolescents 

 – An Evidence-Based Review of Psychosocial Treatments for Bipolar Disorder 

 – Genetics Of Bipolar Disorder 

Bipolar Affective Disorder: Does Psychosocial Treatment Add To The Efficacy Of Drug Therapy?

The Neurobiology Of Bipolar Disorder

Expert Consensus Guidelines For The Medication Treatment Of Bipolar Disorder: A New Treatment Tool

A Test For Bipolar Disorder: The Mood Disorder Questionnaire 

STEP- BD—A Design For Evaluating Effectiveness Of Treatment For Bipolar Disorder

The TEN Interview: Kay Redfield Jamison, PhD

Attention-Deficit/Hyperactivity Disorder And Pediatric-Onset Bipolar Disorder 


 – Monoarthritis Induced by Bupropion Hydrochloride

 – Bupropion Sustained Release for Panic Disorder 

 – Effect of Bupropion SR on Specific Symptom Clusters of Depression: Analysis of the 31-Item Hamilton Rating Scale for Depression 


 – A Primer on Caffeine Pharmacology and Its Drug Interactions in Clinical Psychopharmacology


 – Recent-Onset Schizophrenia and Adolescent Cannabis Use: MRI Evidence for Structural Hyperconnectivity?

 – Cessation of Cannabis Use by Patients with Recent-Onset Schizophrenia and Related Disorders


 – Citalopram Versus Amitriptyline in Elderly Depressed Patients with or without Mild Cognitive Dysfunction: A Danish Multicentre Trial in General Practice

 – Can Physiologic Assessment and Side Effects Tease Out Differences in PTSD Trials? A Double-Blind Comparison of Citalopram, Sertraline, and Placebo

 – Overview of the Safety of Citalopram

 – Citalopram for the Treatment of Adolescent Anxiety Disorders: A Pilot Study

Efficacy Comparison Of Escitalopram And Citalopram In The Treatment Of Major Depressive Disorder: Pooled Analysis Of Placebo-Controlled Trials

Clinical Trials (standards & strategies)

 – A Pilot Evaluating Clinical Pharmacy Services in an Ambulatory Psychiatry Setting

 – Rater Training for a Multi-Site, International Clinical Trial: What Mood Symptoms may be most Difficult to Rate?

 – Which Rating Scales are Regarded as ‘The Standard’ in Clinical Trials for Schizophrenia? A Critical Review

 – Statistical Strategies for Randomized Controlled Clinical Trials to Detect Differential Onset of Action

 – Assessment of Anxiety in Clinical Trials with Depressed Patients Using the Hamilton Depression Rating Scale

 – The Sex Effects Scale: Pilot Validation in a Healthy Population

 – Exercise for Depression: Efficacy, Safety and Clinical Trial Implications

 – Psychometric Evaluation of a Patient-Rated Troubling Symptom Scale for Generalized Anxiety Disorder Clinical Trials

 – Addressing Methodological Issues in Studying Antidepressant Onset Efficacy Using Prespecified Sensitivity Analyses

 – Early Symptom Change Prediction of Remission in Depression Treatment

 – Placebo Response in Depression: A Perspective for Clinical Practice

 – Psychometric Evaluation of a Patient-Rated Troubling Symptom Scale for Generalized Anxiety Disorder Clinical Trials

 – Developing and Testing Adaptive Treatment Strategies Using Substance-Induced Psychosis as an Example.

 – Simple Options for Improving Signal Detection in Antidepressant Clinical Trials

 – Reliability and Validity of the Yale-Brown Obsessive-Compulsive Scale in Schizophrenia Patients

 – What Is a Significant Response in Drug Studies of Attention- Deficit/Hyperactivity Disorder: Statistical Significance Is Necessary, But Is It Sufficient?

 – An Intent-to-Treat Method for Enhancing Analysis of Clinical Trials with Rescue Medication: A Mixed-Model Approach

 – The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) Approach

 – Informant-Rated Cognitive Symptoms in Normal Aging, Mild Cognitive Impairment, and Dementia

 – Clinical Trials in Alzheimer’s Disease

Placebo-Controlled Trials In Psychiatric Research: An Ethical Perspective

Ethics And Economics In Placebo-Controlled Trials Of New Drugs For Mood Disorders

Reconsidering Outcomes In Alzheimer Disease Clinical Trials


 – A Case of Hyper Sexuality Probably Associated with Clozapine

 – Differences in Efficacy on Substance Abuse between Risperidone and Clozapine Supports the Importance of Differential Modulation of Dopaminergic Neurotransmission

 – Amisulpride for Clozapine Induced Sialorrhea

 – Clinical Predictors of Response to Clozapine in Patients with Treatment Resistant Schizophrenia

 – Suicidal Obsessions as Dose Dependent Side-Effect of Clozapine

 – Complete Resolution of Clozapine-Induced Sialorrhea with Low Dose Trihexyphenidyl

 – Amisulpride for Clozapine Induced Sialorrhea

 – Factors Associated with Response to Clozapine in Schizophrenia: A Review

 – Switching antipsychotics, pharmacokinetics, pharmacodynamics, crossover, abrupt switch, clozapine, olanzapine, ziprasidone


 – Cocaine is a Major Risk Factor for Antipsychotic Induced Akathisia, Parkinsonism and Dyskinesia.

 – Acute Cortisol Administration Triggers Craving in Individuals with Cocaine Dependence


 – A Pilot Evaluating Clinical Pharmacy Services in an Ambulatory Psychiatry Setting