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Articles In Press2018-07-13T13:42:28-07:00

The following articles are currently In Press and will be published in the next issue of
Psychopharmacology Bulletin

The Effect of Organic Lithium Salts on Plasma 8-Hydroxy-2’-Deoxyguanosine in Bipolar Patients In Vitro

By Prokopieva Valentina, Yarygina Ekaterina, Bokhan Nikolay, Plotnikov Evgenii


Objectives: An important step in the development of new drugs for the treatment of bipolar disorder (BD) is the study of the extent to which novel lithium salts whose anionic component has an antioxidant effect can reduce oxidative DNA dam-age in human blood plasma in vitro. We investigated the effects of lithium salts con-taining different organic anionic components (lithium carbonate (Li-CAR), pyruvate (Li-PYR), succinate (Li-SUC), fumarate (Li-FUM) and ascorbate (Li-ASC)) on levels of the oxidative damage product of DNA—8-hydroxy-2’-deoxyguanosine (8-OH-dG) in blood plasma after incubation of blood samples from healthy individuals (healthy group) and patients with bipolar disorder (BD-group) with these chemical compounds. Methods: Blood incubation was carried out in the presence of lithium salts (1.2 mM) for 1 hour at 37°C. Measurement of 8-OH-dG concentrations in blood plasma was carried out by enzyme immunoassay using a DNA Damage Competitive Elisa Kit (Thermo Fisher Scientific, USA). Results: In samples without compounds (control), concentrations of 8-OH-dG in the BD-group did not differ from the group of healthy individuals. None of the tested compounds had a significant effect on 8-OH-dG in healthy individuals. In BD patients, Li-PYR significantly reduced levels of plasma 8-OH-dG, while other compounds did not have a noticeable effect. Conclusion: Lithium pyruvate reduces oxida-tive DNA damage in the blood of BD patients in vitro, demonstrating the potential of this compound to function not only as a mood stabilizer, but also as an antioxidant and cytoprotector.

February 25th, 2020|

Psychiatric Prescribing Patterns for Depression Treatment in an Outpatient Depression Clinic

By Roberta E. Wilson, Sarah Choi, Sagar V. Parikh, Jolene R. Bostwick


Objective: To elucidate psychiatric prescribing patterns for depression treatment in patients being seen by an outpatient depression clinic as of 2018. Experimental Design: Single-center, observational analysis. Principle Observation: Selective serotonin receptor inhibitors are most commonly used by patients, and the majority of trials have adequate duration (2 months or longer). Conclusion: Healthcare providers observed in this study follow depression treatment guidelines and ensure medications are given an adequate trial.

February 25th, 2020|

Spontaneous Ejaculation Induced with Atomoxetine

By Ferhat YAYLACI, Begüm ŞAHBUDAK, and Önder KÜÇÜK


Attention Deficit and Hyperactivity Disorder is one of the most common psychiatric disorders of childhood, characterized by attention deficit, hyperactivity and impulsivity. The most effective treatment in ADHD is drug treatment. Stimulant and nonstimulant drug t