21 03, 2019

Biogen, Eisai discontinue Alzheimer’s trials

By |2019-03-21T18:28:53-07:00March 21st, 2019|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

Biogen and Eisai have announced that they are discontinuing the ENGAGE and EMERGE trials, which were designed to test the efficacy and safety of aducanumab in patients with mild cognitive impairment caused by Alzheimer’s disease and mild Alzheimer’s disease dementia. The phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group trials were [...]

20 03, 2019

FDA Approves Brexanolone, First Drug for Postpartum Depression

By |2019-03-20T11:48:10-07:00March 20th, 2019|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

The US Food and Drug Administration (FDA) has approved brexanolone intravenous infusion (Zulresso, Sage Therapeutics), the first-ever drug indicated for the treatment of postpartum depression. The drug is administered under medical supervision as a continuous infusion over a total of 60 hours (2.5 days), according to the FDA. Postpartum depression can [...]

6 03, 2019

Alzheimer Drug Plus SSRI May Improve Depression/Cognition

By |2019-03-06T13:40:42-07:00March 6th, 2019|Brief Bulletins from the Field, Uncategorized, We Know Psychiatry|0 Comments

Adding the Alzheimer drug memantine (Namenda, Allergan) to treatment with a selective serotonin reuptake inhibitor may improve depressive symptoms, executive function, and other outcomes in older patients with both depression and cognitive complaints, new research suggests. The findings were presented at the American Association of Geriatric Psychiatry (AAGP) 2019. In a [...]

6 03, 2019

FDA Approves Intranasal Ketamine for Major Depressive Disorder

By |2019-03-06T08:05:04-07:00March 6th, 2019|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

The Food and Drug Administration yesterday approved an intranasal form of esketamine for treatment-resistant depression in adults who have failed at least two oral antidepressants of different classes. The spray, from Janssen Pharmaceutical (Spravato) is available in tamper-resistant prepackaged units of one, two, or three devices to deliver the prescribed doses [...]

15 02, 2019

Improved efficacy of pregabalin by restoring plasma vitamin D levels in migraine: a case report.

By |2019-02-15T12:23:46-07:00February 15th, 2019|Articles In Press|0 Comments

Antonio Siniscalchi, MD; Piergiorgio Lochner; Erika Cione, PhD; Adelia Michniewicz, Biotechnologist; Vincenzo Guidetti, MD; Luca Gallelli, MD Abstract Migraine appears to be the most common neurological syndrome in primary care. Pain in migraine is mediated by the release of inflammatory mediators at the level of nerves and blood vessels. The antioxidant and neuroprotective effects of [...]

15 02, 2019

Successful Resolution of Prominent Somatic Delusions following Bi-temporal Electroconvulsive Therapy in a patient with Treatment- Resistant Schizoaffective disorder

By |2019-02-15T12:07:40-07:00February 15th, 2019|Articles In Press|0 Comments

Joshua L. Cohen, PhD; My-Hanh Thi Vu, MD; Mirza Adam Beg, BS; Soumya Sivaraman, MD; and Badari Birur, MD Abstract Somatic delusions occur in a variety of psychiatric disorders including schizophrenia, major depressive disorder, and bipolar disorder. Somatization is associated with lower quality of life and greater risk for suicide. Treatment [...]

18 01, 2019

Combination of Ketamine and Naltrexone Shows Promise for Addiction Treatments and Depression

By |2019-01-18T11:06:43-07:00January 18th, 2019|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

  A preliminary study of five patients suffering from both depression and substance abuse disorders suggest that isn’t the case. The study was published Jan. 9 in the journal JAMA Psychiatry. Substance abuse and depression are common in many patients, and efforts to treat both conditions simultaneously have had limited [...]

6 12, 2018

Study Links Increased Risk of Mental Disorders with Childhood Infections

By |2018-12-06T11:40:55-07:00December 6th, 2018|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

Furthering the role of immune system disorders in the development of mental disorders, recent research links infections that children contract during their childhood with increased risk of mental disorders during childhood and adolescence. The first study of its kind shows that high temperatures, sore throats and infections during childhood can [...]

12 09, 2018

Cassipa Approved by FDA for Opioid Dependence

By |2018-09-12T15:28:07-07:00September 12th, 2018|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

A new dosage strength of buprenorphine and naloxone sublingual film was approved recently by the Food and Drug Administration. Cassipa sublingual film, made by Teva Pharmaceuticals, is a 16 mg/4 mg dosage of buprenorphine and naloxone for the maintenance treatment of opioid dependence. Buprenorphine and naloxone sublingual film also is [...]

23 08, 2018

How a Distant Epidemic Came Home to Roost: One Man’s Opioid Addiction

By |2018-09-12T14:58:24-07:00August 23rd, 2018|Brief Bulletins from the Field, We Know Psychiatry|0 Comments

A front page New York Times story read, “Every year, thousands of people addicted to opioids show up at hospital emergency rooms in withdrawal so agonizing it leaves them moaning and agonizing on the floor.” The article then goes on to quote a heroin addict. I would have stopped reading [...]