A Comprehensive Update of Lofexidine for the Management of Opioid Withdrawal Symptoms

By |2020-07-29T09:04:39-07:00July 29th, 2020|Brief Bulletins from the Field|

The current maintenance treatment for opiate withdrawal usually includes using a different, controlled, opiate, either methadone or buprenorphine. Alpha-2 receptor agonists, such as lofexidine, can be used to manage the acute symptoms during withdrawal. Lofexidine is effective and safe and is FDA approved for the management of withdrawal symptoms. It [...]

Naldemedine for the Use of Management of Opioid Induced Constipation

By |2020-07-29T08:59:49-07:00July 29th, 2020|Brief Bulletins from the Field|

According to Urits and Viswanath, Opioid medications are fundamental in anesthesia and analgesia and are often used to treat acute and chronic pain. They achieve their desired effects by modulating pain perception in the central nervous system; however, they also act on opioid receptors in the periphery, causing many undesirable [...]

Antiepileptic Drugs and Bone Health: Current Concepts

By |2020-06-04T10:53:56-07:00June 4th, 2020|Brief Bulletins from the Field, We Know Psychiatry|

Chronic use of antiepileptic drugs (AEDs) can induce the development of adverse effects on bone metabolism. In epileptic patients treated with AED, the monitor- ing of biochemical markers of bone turnover, such as the measurement of serum 25 (OH) vitamin D, bone mineral density, before the beginning of the treatment [...]

Demographic Variation in the Use of Prazosin for Treatment of Sleep Disturbance in Combat Veterans with PTSD

By |2020-06-04T10:47:07-07:00June 4th, 2020|Brief Bulletins from the Field, We Know Psychiatry|

ABSTRACT ~ Objective: Off-label use of prazosin for posttraumatic stress disorder-related sleep disturbances (PTSD-SD) is widespread in Veterans Health Administration (VA) settings, but clinical trials have had mixed results. Trial criteria may exclude significant sub-groups, and therefore a 2018 study may not provide the final evidence of prazo- sin efficacy [...]