A novel blood test that detects a key biomarker for Alzheimer’s disease (AD) could help physicians more accurately determine the presence and track disease progression. The test measures levels of the protein MTBR-tau243 — microtubule-binding region of tau containing the residue 243 — a biomarker of tau tangles in the [...]
Neurocrine Biosciences presented new data from the long-term, open-label KINECT 4 study demonstrating remission of tardive dyskinesia (TD) among most patients treated with once-daily valbenazine (Ingrezza) capsules, at the 2025 Psychiatry Update Conference in Chicago.1 The conference was first reported in Psychiatric Times "These findings further establish Ingrezza as a [...]
Objective Postpartum depression (PPD), now referred to as perinatal depression, is a prevalent and debilitating mood disorder that reduces health-related quality of life (HRQoL) and psychosocial functioning. Esketamine, which is efficacious in adults with treatment-resistant depression and individuals with depression and suicidality, is also analgesic in pain management during childbirth [...]
Objective Many psychotropic drugs are highly associated with related weight gain. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are established anti-obesity and glucose-lowering agents. Preliminary evidence also indicates they are fit for purpose in mitigating psychotropic drug-related weight gain (PDWG). This systematic review aims to synthesize the extant evidence from randomized controlled [...]
Background In VIVRE (NCT04448431), vortioxetine was associated with significantly higher rates of symptomatic and functional remission, better daily and social functioning, and greater treatment satisfaction than desvenlafaxine in patients with major depressive disorder (MDD) and partial response to selective serotonin reuptake inhibitor (SSRI) therapy. This analysis further explored the relative [...]
According to a brief on Medscape, supported by the NIH, The use of general anesthesia during cesarean deliveries is associated with an increased risk for postpartum depression (PPD) that necessitates hospitalization as well as a risk for suicidality, regardless of obstetric complications. Researchers conducted a retrospective cohort study to assess [...]
Writing in Psychopharmacology Bulletin, Trishna Sharma, Annette C. Kestner and Abhishek Reddy described a 17-year-old female with a history of NT1 and no past psychiatric history presented to the hospital from the community due to a psychotic episode of unknown etiology. During this event, she was told by “the Lord” [...]
Writing in Psychopharmacology Bulletin, authors Chinenye Okoro, Kaye Homer, Marlene Kelbrick, Jonny Walker, Mary Sam, Justine Burge, Rosie Richards, Gabriela Paduret, and Feras Ali Mustafa examined a 53-year-old Caucasian female who had been under the care of the early intervention for psychosis (EIP) service following a first episode psychosis. At [...]
Ahmed Naguy, Nadyah Alayadhi, Saxby Pridmore, Bibi Alamiri, writing in Psychopharmacology Bulletin, made the following observations: An 11-year-old male Qatari boy was brought in to hospital by his parents for episodic behavioural dyscontrol. He was a known case of essential Autism spectrum disorder (ASD) with mild intellectual disability (FSIQ = [...]
Salt is found in nearly every kitchen across the world; however, it is not typically thought of to be a means for suicide. Depending on the age and size of the person, anywhere from 2 to 4 tablespoons of salt consumed rapidly can be lethal. To put that in perspective, [...]