Our Current Understanding of Genetic Alterations in Colorectal Cancer, and Implications for Clinical Use
By Manel Esteller, MD, PhD, and Montserrat Sanchez-Cespedes, PhD
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Flavonoids Join the War on Cancer
By Uwe Wenzel, PhD
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Pharmacy Practice
Oral Chemotherapy for Colorectal Cancer: An Update
By Sunil Sharma, MD
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Pharmacy Practice
In Vitro Tests to Predict Human Tumor Sensitivity to Cytotoxic Agents
By Axel-R. Hanauske, MD, PhD
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Pharmacy Practice
An Update on Cancer Chemoprevention
By Tammy Chernin, RPh
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Letter From the Editors: A Question of Ownership
By Daniel D. Von Hoff, MD, and J. Lyle Bootman, PhD
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Critical Analysis of Recent Phase III Studies for the Treatment of Colorectal Cancer Implications for Future Clinical Trial Design
DISCUSSANTS: John S. Macdonald, MD, Richard Goldberg MD, Leonard B. Saltz, MD, Daniel G. Haller, MD,
and Richard Simon, DSc
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Metastasis-Suppressor Genes: A Review and Perspective on an Emerging Field
By Barbara A. Yoshida, Mitchell M. Sokoloff, Danny R. Welch, and Carrie W. Rinker-Schaeffer
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Sequential Chemotherapy for the Curative Treatment of Squamous Cell Cancer of the Head and Neck: A New Paradigm
By Marshall R. Posner, MD
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Pharmacy Practice
Monitoring Chemotherapy in an Aging Population
By Judith A. Smith, Pharm.D, BCOP
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Breast Imaging: Economic Issues and Challenges
By Dione M. Farria, MD, MPH, and Stephen A. Feig, MD
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A Systematic Approach to Improving Care for Cancer Patients: Focus on Growth Factor Use and Outcomes
By Kimberly A. Bergstrom, PharmD, and Eric T. Herfindal, PharmD, MPH
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Letter From the Editors
Are We Prepared for the Genomics Era?
By J. Lyle Bootma
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The Genetics of Multiple Myeloma
By Brian Van Ness, PhD
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Diagnosis and Treatment of Depression in the Cancer Patient
Tracy L. Skaer, PharmD, Linda M. Robison, MSPH, David A. Sclar, PhD
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High-Dose Therapy in Patients with Multiple Myeloma
By Bhawna Sirohi, MBBS, DCH and Ray Powles, MD, MRCP, MRCPath
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Pharmacology and Therapeutic Use of Trastuzumab in Breast Cancer
By Imad Treish, PharmD, Rowena Schwartz, PharmD, BCOP, and Celeste Lindley, PharmD, BCPS, FASHP, FCCP
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Guest Editor
Research Needs in Myeloma
Gregory R. Mundy, MD
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Colorectal Cancer Screening: How Are We Doing and How Can We Improve?
Virender K. Sharma, MD, and Colin W. Howden, MD
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Increased Mortality Risk Associated With Medial Breast Tumors May Be Due to Untreated Internal Mammary Node Metastases
Caroline Lohrisch, MD