Our Current Understanding of Genetic Alterations in Colorectal Cancer, and Implications for Clinical Use
By Manel Esteller, MD, PhD, and Montserrat Sanchez-Cespedes, PhD
Flavonoids Join the War on Cancer
By Uwe Wenzel, PhD
Pharmacy Practice
Oral Chemotherapy for Colorectal Cancer: An Update
By Sunil Sharma, MD
In Vitro Tests to Predict Human Tumor Sensitivity to Cytotoxic Agents
By Axel-R. Hanauske, MD, PhD
An Update on Cancer Chemoprevention
By Tammy Chernin, RPh
Letter From the Editors: A Question of Ownership
By Daniel D. Von Hoff, MD, and J. Lyle Bootman, PhD
Critical Analysis of Recent Phase III Studies for the Treatment of Colorectal Cancer Implications for Future Clinical Trial Design
DISCUSSANTS: John S. Macdonald, MD, Richard Goldberg MD, Leonard B. Saltz, MD, Daniel G. Haller, MD,
and Richard Simon, DSc
Metastasis-Suppressor Genes: A Review and Perspective on an Emerging Field
By Barbara A. Yoshida, Mitchell M. Sokoloff, Danny R. Welch, and Carrie W. Rinker-Schaeffer
Sequential Chemotherapy for the Curative Treatment of Squamous Cell Cancer of the Head and Neck: A New Paradigm
By Marshall R. Posner, MD
Monitoring Chemotherapy in an Aging Population
By Judith A. Smith, Pharm.D, BCOP
Letter From the Editors
Are We Prepared for the Genomics Era?
By J. Lyle Bootma
The Genetics of Multiple Myeloma
By Brian Van Ness, PhD
High-Dose Therapy in Patients with Multiple Myeloma
By Bhawna Sirohi, MBBS, DCH and Ray Powles, MD, MRCP, MRCPath
Pharmacology and Therapeutic Use of Trastuzumab in Breast Cancer
By Imad Treish, PharmD, Rowena Schwartz, PharmD, BCOP, and Celeste Lindley, PharmD, BCPS, FASHP, FCCP
Guest Editor
Research Needs in Myeloma
Gregory R. Mundy, MD
Colorectal Cancer Screening: How Are We Doing and How Can We Improve?
Virender K. Sharma, MD, and Colin W. Howden, MD
Increased Mortality Risk Associated With Medial Breast Tumors May Be Due to Untreated Internal Mammary Node Metastases
Caroline Lohrisch, MD
Pharmacoeconomics of Cisplatin-Based Chemoradiation in Cervical Cancer: A Review
Peter G. Rose, MD, and Panos T. Lappas
New Medicines in Development for Cancer
Pharmaceutical Research and Manufacturers of America (PhRMA)
Publisher’s Statement
Raising Cain
James M. La Rossa Jr.
A Singleness of Purpose— A Spectrum of Expertise and Care— What Will the Future Bring?
J. Lyle Bootman, PhD Co-Editor
Daniel D. Von Hoff, MD Co-Editor
Enfoque clínico
Reflexiones sobre salud mental infantil en el contexto de latinoamerica
Dr. Edgard Belfort
Conductas suicidas en adolescentes brasileños: análisis exploratorio de prevalencia y factores de riesgo
Dra. Cristiane S. Duarte, Dra. Isabel A.S. Bordin, Magister Cristiane S. de Paula y Dra. Christina W. Hoven
Caso clínico
Delirium por Clorhidrato de Trihexifenidilo
Dr. Andrés Heerlein y Dr. Jaime Solís
Psicofarmacología y Neurociencia
Genoma Humano y Psiquiatría
Dr. Humberto Nicolini
Nota del editor invitado
Psiquiatría infantil en América Latina: gran demanda
Dr. Carlos E. Berganza
Reseña educativa
Manejo clínico de las disfunciones sexuales inducidas por antipsicóticos en la esquizofrenia
Lic. Anna Maria Niccolai Costa, Dr. Mauricio Silva de Lima y Dr. Jair de Jesus Mari
Evaluacion de servicios de salud mental: el caso de la efectividad de las psicoterapias
Dr. Ramón Florenzano
Tratamientos psicosociales para el trastorno por estrés postraumático
Dra. Barbara Oslav Rothbaum
Avances en la farmacoterapia del trastorno por estrés postraumático
Dr. Charles R. Marmar, Dr. Thomas C. Neylan y Dr. Frank B. Schoenfeld
Componentes cognitivos y biológicos que participan en el desarrollo del trastorno por estrés postraumático
Dra. Sarah L. Halligan y Dra. Rachel Yehuda