The Genetics of Multiple Myeloma
By Brian Van Ness, PhD
Letter From the Editors
Are We Prepared for the Genomics Era?
By J. Lyle Bootma
A Systematic Approach to Improving Care for Cancer Patients: Focus on Growth Factor Use and Outcomes
By Kimberly A. Bergstrom, PharmD, and Eric T. Herfindal, PharmD, MPH
Breast Imaging: Economic Issues and Challenges
By Dione M. Farria, MD, MPH, and Stephen A. Feig, MD
Pharmacy Practice
Monitoring Chemotherapy in an Aging Population
By Judith A. Smith, Pharm.D, BCOP
Sequential Chemotherapy for the Curative Treatment of Squamous Cell Cancer of the Head and Neck: A New Paradigm
By Marshall R. Posner, MD
Metastasis-Suppressor Genes: A Review and Perspective on an Emerging Field
By Barbara A. Yoshida, Mitchell M. Sokoloff, Danny R. Welch, and Carrie W. Rinker-Schaeffer
Critical Analysis of Recent Phase III Studies for the Treatment of Colorectal Cancer Implications for Future Clinical Trial Design
DISCUSSANTS: John S. Macdonald, MD, Richard Goldberg MD, Leonard B. Saltz, MD, Daniel G. Haller, MD,
and Richard Simon, DSc
Letter From the Editors: A Question of Ownership
By Daniel D. Von Hoff, MD, and J. Lyle Bootman, PhD
An Update on Cancer Chemoprevention
By Tammy Chernin, RPh
In Vitro Tests to Predict Human Tumor Sensitivity to Cytotoxic Agents
By Axel-R. Hanauske, MD, PhD
Oral Chemotherapy for Colorectal Cancer: An Update
By Sunil Sharma, MD
Flavonoids Join the War on Cancer
By Uwe Wenzel, PhD
Our Current Understanding of Genetic Alterations in Colorectal Cancer, and Implications for Clinical Use
By Manel Esteller, MD, PhD, and Montserrat Sanchez-Cespedes, PhD
Palliative Chemotherapy for Advanced Colorectal Cancer
By Peter Simmonds, FRACP, and Tim Iveson, MD
Addressing the Quality Chasm for a New Health System in the 21st Century
By J. Lyle Bootman, PhD, and Daniel D. Von Hoff, MD
Surveying the Field of Gynecologic Oncology
By William J. Hoskins, MD
Surgical Management of Epithelial Ovarian Cancer
By George Coukos, MD, PhD, and Stephen C. Rubin, MD
The Role of Irradiation in Endometrial Cancer
By Perry W. Grigsby, MD
Diagnosis and Staging of Gynecological Malignancies
By Brigitte E. Miller, MD
Chemotherapy for Epithelial Ovarian Cancer
By Maurie Markman, MD
Managing Deep Vein Thrombosis Risk in Oncology Patients Office and Outpatient Settings
MODERATOR: Brian A. Meltzer, MD, MBA
DISCUSSANTS: Leo R. Zacharski, MS, MD, and Steven R. Deitcher, MD
A Standing Ovation for a Change in How We Treat Patients With Cancer —Forever
By Daniel D. Von Hoff, MD, FACP, and J. Lyle Bootman PhD
The Case for Geriatric Oncology
By Lodovico Balducci, MD
Pharmacology of Antineoplastic Agents in Older Cancer Patients
By J. Andrew Skirvin, PharmD, Sunitha Vemulapalli, MD, and Stuart M. Lichtman, MD
The Controversial Association of the Treatment of Infertility With Fertility Agents and Development of Ovarian Cancer:
What Should Patients Be Told?
By Judith A. Smith, PharmD, BCOP
Assessing the Older Cancer Patient
By Martine Extermann, MD, PhD
Metastasis of an Esophageal Carcinoma to the Soft Tissue in the Elbow
By Arun Kumar, MD, Rajeev Kulkarni, MD, Emmanuel C. Besa, MD, and Carolyn E. Grotkowski, MD
Cancer Mortality in the Elderly, 1960–1998: A Worldwide Approach
By Carlo La Vecchia, MD, Franca Lucchini, BSc, Eva Negri,ScD, and Fabio Levi, MD
Use of Colony-Stimulating Factors in the Elderly Cancer Patient
By Gary H. Lyman, MD, MPH, FRCP (Edin), Lodovico Balducci, MD, and Yemi Agboola, MS
Right Tool, Right Time, Right Reason
By J. Lyle Bootman, PhD, and Daniel D. Von Hoff, MD, FACP
Palliative Care Options for Advanced Prostate Cancer
By Amir V. Kaisary, MA, ChM, FRCS, and Ross Knight, MRCS
Treatment and Management of Cancer in the Frail Elderly
By Zeba S. Geloo, MD, and William B. Ershler, MD
Surgical Staging for Endometrial Cancer
By James W. Orr, Jr, MD, Phillip Y. Roland, MD, Pamela J. Orr, RN, OCN, and Dara D. Leichter, RN, OCN
The Metabolism of Prostate Malignancy:
Insight Into the Pathogenesis of Prostate Cancer and New Approaches for Its Diagnosis and Treatment
By Leslie C. Costello, PhD, and Renty B. Franklin, PhD
The Contemporary Management of Colorectal Cancer
By David L. Grinblatt, MD, and Richard L. Schilsky, MD
Prostate Cancer Immunotherapy: Choices for Patients and Clinicians
By Michael L. Salgaller, PhD
Are You Ready For Some Ethics, Some Success, Some Cytoprotectants, and Some New Board Members?
By Daniel D. Von Hoff, MD, FACP, and J. Lyle Bootman, PhD
Oncology Ethics Forum
Ethical Perspectives on Oncology Care
By Terri Maxwell, RN, MSN, AOCN
Economics of Cancer Drug Development
By Michael Dickson, PhD, and Gene Reeder, PhD