Loxapine | Adasuve

ADASUVE is a typical antipsychotic indicated for the acute treatment of agitation associated with schizophrenia or bipolar I disorder in adults. Efficacy was demonstrated in 2 trials in acute agitation: one in schizophrenia and one in bipolar I disorder (1, 14) Limitations of Use: ADASUVE must be administered only in an enrolled healthcare facility (1)

Dosage and Administraion:

  • Must be administered only by a healthcare professional (2.1)
  • 10 mg by oral inhalation using an inhaler (2.1)
  • Administer only a single dose within any 24-hour period (2.1)
  • Prior to administering, screen all patients for a history of pulmonary disease, and examine patients (including chest auscultation) for respiratory abnormalities (e.g. wheezing) (2.2)
  • Refer to Full Prescribing Information for important instructions on use of the ADASUVE inhaler (2.3)
  • After administration, monitor patients for signs and symptoms of bronchospasm at least every 15 minutes for at least one hour (2.4)

Dosage Forms and Strengths

  • Inhalation powder: 10 mg unit in a single-use inhaler (3)

Loxapine | Adasuve Prescribing Information Highlights

The following points are shortened, highlighted information from prescribing information for this drug. For the full prescribing information PDF, click the button below to be directed to the FDA PDF label for this drug.


  • See description above.


  • See description above.


  • Current diagnosis or history of asthma, chronic obstructive pulmonary disease (COPD), or other lung disease associated with bronchospasm (4)
  • Acute respiratory signs/symptoms (e.g., wheezing) (4)
  • Current use of medications to treat airways disease, such as asthma or COPD (4)
  • History of bronchospasm following ADASUVE treatment (4)
  • Known hypersensitivity to loxapine or amoxapine (4)


  • Neuroleptic Malignant Syndrome: May develop in patients treated with antipsychotic drugs. Discontinue treatment (5.4)
  • Hypotension and Syncope: Use with caution in patients with known cardiovascular or cerebrovascular disease (5.5)
  • Seizure: Use with caution in patients with a history of seizures or with conditions that lower the seizure threshold (5.7)
  • Potential for Cognitive and Motor Impairment: Use caution when driving or operating machinery (5.8)
  • Cerebrovascular Adverse Reactions: Increased incidence of stroke and transient ischemic attack in elderly patients with dementia-related psychosis treated with antipsychotic drugs (5.9)


  • Most common adverse reactions (incidence ≥ 2% and greater than placebo) were dysgeusia, sedation, and throat irritation (6.1)

More Information on Loxapine | Adasuve

For more information on this drug and dozens of other leading psychotropics, see our 2018 Black Book of Psychotropic Dosing and Monitoring. Available as a digital PDF download.