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Despite the rising breast cancer incidence in the United States (US), the death rate from it has been decreasing over the past decade. While some of the decrease in mortality can be attributed to a broader use of screening mammography, a significant portion of this is also due to the increased use of systemic therapies in the adjuvant setting. Identification of effective new agents for the treatment of metastatic disease has also resulted in prolonged survival and improved quality of life.