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Table Of Contents

5 Foreword

By Charles B. Nemeroff,MD, PhD

6 Recent Advances in the Neurobiology of Depression

By Charles B. Nemeroff,MD, PhD

24 New Goals in the Treatment of Depression: Moving Toward Recovery

By Michael E. Thase,MD, and Philip T. Ninan,MD

36 Long-Term Treatment Strategies in Affective Disorders

By Martin B. Keller,MD

49 New Developments in the Neurobiological Basis of Anxiety Disorders

By Jack M. Gorman,MD, Robert M. A. Hirschfeld,MD, and Philip T. Ninan,MD

68 Generalized Anxiety Disorder:Raising the Expectations of Treatment

By Christer Allgulander,MD, and David V. Sheehan,MD, MBA

79 Long-Term Treatment Strategies in Anxiety Disorders

By Christer Allgulander,MD, Robert M. A.Hirschfeld,MD, and David J.Nutt,MD, PhD

93 Optimizing Treatment Outcomes for Patients With Depression and Generalized Anxiety Disorder

By Michael E. Thase,MD, and Madhukar Trivedi,MD

103 Coping With Somatic Comorbidities: Striving for Complete Recovery

By Christer Allgulander,MD, and Siegfried Kasper,MD

112 Depression in the Elderly

By William M. McDonald,MD, Carl Salzman,MD, and Alan F. Schatzberg,MD

123 Mechanism of Action of Antidepressants

By Francesc Artigas, PhD, David J. Nutt,MD, PhD, and Richard Shelton,MD

133 Depression Treatment: A Lifelong Commitment?

By Martin B. Keller,MD, and Ernst R. Berndt, PhD

142 Algorithms in Clinical Psychiatry: A Stepped Approach Toward the Path to Recovery

By Madhukar Trivedi,MD

150 Unraveling the Diagnostic Clues of Depression and GAD: The Primary Care Challenge

By Johan A. den Boer,MD, Dwight L. Evans,MD, Sing Lee,MD, PhD, and Rafael Salin-Pascual,MD

158 Can We Distinguish Anxiety From Depression?

By David S. Baldwin, FRCPsych, Dwight L. Evans,MD, Robert M. A. Hirschfeld,MD, and Siegfried Kasper,MD

166 Raising the Expectations of Long-Term Treatment Strategies in Anxiety Disorders

By Martin B. Keller,MD