Psychotropics and Related Topics From
Sixteen Years of Peer-Review Articles
NOTE FOR READERS: While most pharmacologic agents are called out by name, some articles may be overviews of entire classes of agents. For example, under sections such as ANTIDEPRESSANTS (not specified), the reader would find the following article: Rational Antidepressant Selection: Applying Evidence-Based Medicine to Complex Real-World Patients.
Likewise, certain pharmacologic advances can be rationalized only in the context of the disease itself. Among drug categories, you will find ‘non specified’ sections on Epidemiology, Bipolar, and Sleep Disturbances, to name just a few. Rather than omit entire categories of research because they did not correspond to a strict listing of drug names, we chose to deviate in certain instances for the sake of completeness. We hope this does not contribute to any confusion.
All articles prefaced with the 
logo are indexed on PubMed.com under Psychopharmacol Bull.
— Sincerely, The Editors
DISCLAIMER: Although every effort has been made to ensure that drug information is presented accurately in all Medworks’ publications, the ultimate responsibility rests with the prescribing physician. Neither the publisher, nor the authors can be held responsible for errors or for any consequences arising from the use of information contained herein. Readers are strongly urged to consult additional relevant primary literature. No claims or endorsements are made for any drug or compound currently under clinical investigation.
Dosing and Monitoring Guides
– 2018 Update: Dosing and Monitoring: Children and Adolescents
– 2018 Update: The Black Book of Psychotropic Dosing and Monitoring
Rating Scales
– Rating Scales And Safety Measurements In Bipolar Disorder And Schizophrenia – A Reference Guide
Depression Rating Scales – A Doctor’s Guide
Wender Utah Rating Scale (WURS)
Vanderbilt ADHD Diagnostic Teacher Rating Scale
Vanderbilt ADHD Diagnostic Parent Rating Scale
Adult ADHD Self-Report Scale (ASRS-V1.1) Symptom Checklist
Zung Self-Rating Depression Scale
Major (ICD-10) Depression Inventory
Mini-Mental State Examination (MMSE)
The Hamilton Rating Scale For Depression
Cornell Scale For Depression In Dementia
ADHD (Not Specified)
– Unmet Medication Coverage Needs among Adults with Attention Deficit/Hyperactivity Disorder (ADHD)
Agomelatine
– Agomelatine for Depression in Schizophrenia: A Case-Series
Alprazolam
– The Speed of Onset of Action of Alprazolam-XR Compared to Alprazolam-CT in Panic Disorder
Alzheimer’s
Alternative Medicine
– Determinants of Complementary and Alternative Medicine Use by Patients with Bipolar Disorder
Ambulatory Pschiatry (Not Specified)
Amisulpride
– Amisulpride for Clozapine Induced Sialorrhea
Amitriptyline
Anticonvulsants (not specified)
– Evidence-Based Mental Health Use of Anticonvulsants During Pregnancy
– Pharmacokinetics of Mood Stabilizers and New Anticonvulsants
Innovative Treatment Strategies With Anticonvulsants: A Focus On Bipolar Disorder
Antidepressants (not specified)
– Rational Antidepressant Selection: Applying Evidence-Based Medicine to Complex Real-World Patients
– Comparing The Methods Used To Compare Antidepressants
– A Survey of Prescribing Preferences in the Treatment of Refractory Depression: Recent Trends
Great Expectations In Stereochemistry: Focus On Antidepressants
A Discussion On The Methodologies Used To Evaluate Antidepressants
Antipsychotics (not specified)
– Do Long-Acting Injectable Antipsychotics Prevent or Delay Hospital Readmission?
– Lack of Efficacy of Antipsychotics on Premenstrual Psychosis: A Case Report
– Antipsychotic Induced Symptomatic Hyperprolactinemia: Are Dopamine Agonists Safe?
– Metabolic Syndrome with Different Antipsychotics: A Multicentre Cross-Sectional Study
– Antipsychotic Medications and Sudden Cardiac Death
– Antipsychotic-Induced Hyperprolactinemia and Sexual Dysfunction
– Sexual Side Effects Associated With Conventional and Atypical Antipsychotics
– Therapeutic Drug Monitoring of Antipsychotics
–Sex Differences In Antipsychotic Related Metabolic Functioning In Schizophrenia Spectrum Disorders
Arpiprazole Lauroxil
Atomoxetine
– Atomoxetine Induced Hypothermia: A Case Report
Aripiprazole
– An Open-Label Assessment of Aripiprazole in the Treatment of PTSD
– Efficacy of High-Dose Aripiprazole for Treatment-Resistant Schizoaffective Disorder: A Case Report
-Aripiprazole-Induced Asymptomatic Hypertension: A Case Report
Asenapine
– An Open Label Pilot Study Of Adjunctive Asenapine For The Treatment Of Posttraumatic Stress Disorder
Atypical Antipsychotics (not specified)
– The Utilization of Atypical Antipsychotics in the Pain Medicine Physician’s Armamentarium
– Off-Label Second Generation Antipsychotics for Impulse Regulation Disorders: A Review
– Predicting Antipsychotic Use in Children
– Atypical Antipsychotics and Pituitary Neoplasms in the WHO Database
– Mood Stabilizers and Atypical Antipsychotics: Bimodal Treatments for Bipolar Disorder
– Drug Development for Anxiety Disorders: New Roles for Atypical Antipsychotics
– Disturbed Glucose Metabolism Among Patients Taking Olanzapine and Typical Antipsychotics
– Sexual Side Effects Associated With Conventional and Atypical Antipsychotics
Human And Economic Costs Of Schizophrenia: A Case Study Of The Impact Of Newer Antipsychotics
Autism Spectrum Disorder(s) (not specified)
– Treatment Of Autism Spectrum Disorder In Children And Adolescents
– Does Risperidone Improve Hyperacusia in Children with Autism?
Benzodiazepines (not specified)
– Pharmacokinetically Induced Benzodiazepine Withdrawal
Bipolar Disorders (not specified)
– Rating Scales And Safety Measurements In Bipolar Disorder And Schizophrenia – A Reference Guide
– Why Do Persons with Bipolar Disorder Stop Their Medication?
– Bipolar-I Patient Characteristics Associated with Differences in Antimanic Medication Prescribing
– Correlates of Functioning in Bipolar Disorder
– Bipolar-I Depression Outpatient Treatment Quality and Costs in Usual Care Practice
– Patterns of Pharmacotherapy and Treatment Response in Elderly Adults with Bipolar Disorder
– Mood Stabilizers and Atypical Antipsychotics: Bimodal Treatments for Bipolar Disorder
– New Approaches to Modeling Bipolar Disorder
– Management of Bipolar Disorder in Children and Adolescents
– An Evidence-Based Review of Psychosocial Treatments for Bipolar Disorder
– Genetics Of Bipolar Disorder
Bipolar Affective Disorder: Does Psychosocial Treatment Add To The Efficacy Of Drug Therapy?
The Neurobiology Of Bipolar Disorder
Expert Consensus Guidelines For The Medication Treatment Of Bipolar Disorder: A New Treatment Tool
A Test For Bipolar Disorder: The Mood Disorder Questionnaire
STEP- BD—A Design For Evaluating Effectiveness Of Treatment For Bipolar Disorder
The TEN Interview: Kay Redfield Jamison, PhD
Attention-Deficit/Hyperactivity Disorder And Pediatric-Onset Bipolar Disorder
Bupropion
– Monoarthritis Induced by Bupropion Hydrochloride
Caffeine
– A Primer on Caffeine Pharmacology and Its Drug Interactions in Clinical Psychopharmacology
Cannabis
– Cessation of Cannabis Use by Patients with Recent-Onset Schizophrenia and Related Disorders
Citalopram
– Overview of the Safety of Citalopram
– Citalopram for the Treatment of Adolescent Anxiety Disorders: A Pilot Study
Clinical Trials (standards & strategies)
– A Pilot Evaluating Clinical Pharmacy Services in an Ambulatory Psychiatry Setting
– The Sex Effects Scale: Pilot Validation in a Healthy Population
– Exercise for Depression: Efficacy, Safety and Clinical Trial Implications
– Early Symptom Change Prediction of Remission in Depression Treatment
– Placebo Response in Depression: A Perspective for Clinical Practice
– Simple Options for Improving Signal Detection in Antidepressant Clinical Trials
– Reliability and Validity of the Yale-Brown Obsessive-Compulsive Scale in Schizophrenia Patients
– The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) Approach
– Informant-Rated Cognitive Symptoms in Normal Aging, Mild Cognitive Impairment, and Dementia
– Clinical Trials in Alzheimer’s Disease
Placebo-Controlled Trials In Psychiatric Research: An Ethical Perspective
Ethics And Economics In Placebo-Controlled Trials Of New Drugs For Mood Disorders
Reconsidering Outcomes In Alzheimer Disease Clinical Trials
Clozapine
– A Case of Hyper Sexuality Probably Associated with Clozapine
– Amisulpride for Clozapine Induced Sialorrhea
– Clinical Predictors of Response to Clozapine in Patients with Treatment Resistant Schizophrenia
– Suicidal Obsessions as Dose Dependent Side-Effect of Clozapine
– Complete Resolution of Clozapine-Induced Sialorrhea with Low Dose Trihexyphenidyl
– Amisulpride for Clozapine Induced Sialorrhea
– Factors Associated with Response to Clozapine in Schizophrenia: A Review
Cocaine
– Cocaine is a Major Risk Factor for Antipsychotic Induced Akathisia, Parkinsonism and Dyskinesia.
– Acute Cortisol Administration Triggers Craving in Individuals with Cocaine Dependence
Comorbidity
– A Pilot Evaluating Clinical Pharmacy Services in an Ambulatory Psychiatry Setting
Cortisol
– Acute Cortisol Administration Triggers Craving in Individuals with Cocaine Dependence
Cyclobenzaprine
DDTC (a Metabolite of Disulfiram)
Dementia
Depression
Dextromethorphan
Dextromethorphan in Cough Syrup: The Poor Man’s Psychosis
Desvenlafaxine
Dextromethorphan
Donepezil
Drug Interactions (not specified)
– 2018 Update: Dosing and Monitoring: Children and Adolescents
– 2018 Update: The Black Book of Psychotropic Dosing and Monitoring
– Clinical Significance of Drug Binding, Protein Binding, and Binding Displacement Drug Interactions
– Psychoactive Drug Interactions With Pharmacotherapy for Diabetes
– Emerging Role of Drug Interaction Studies in Drug Development:The Good, the Bad, and the Unknown
– Charleston Antidepressant Drug Interactions Surveillance Program (CADISP)
Dopamine D4 Receptors: Neuropsychiatric Implications
Psychotropic Drug Interactions : A Doctor’s Guide
Duloxetine
ECT
– Treatment of Mania in Dementia With Electroconvulsive Therapy
Epidemiology (not specified)
– Epidemiology Of Adolescent Depression
– Pharmacologic And Psychotherapeutic Treatments For Adolescent Depression
– Obesity Cost-Of-Illness Studies: An International Perspective
– Drug Use And Dependence Outside Medical Settings: Recent Epidemiological Evidence
– The Epidemiology of Anxiety Disorders
– Genetic Epidemiology of Drug Use Disorders
– Healthcare Costs For Children With Attention-Deficit/Hyperactivity Disorder
– Expert Consensus Guidelines For The Treatment Of Depression In Women: A New Treatment Tool
– Diagnosis, Epidemiology, And Clinical Course Of Geriatric Depression
– Determinants Of Medical Costs Following A Diagnosis of Depression
Escitalopram
– Escitalopram Induced SIADH in an Elderly Female: A Case Study
Fluoxetine
– Can Fluoxetine Alone Cause Serotonin Syndrome in Adolescents?
– Economic Impact of Olanzapine Plus Fluoxetine Combination Therapy Among Patients Treated for
– Can Serotonin and Fluoxetine Levels in Plasma and Platelets Predict Clinical Response in Depression?
– Intermittent Fluoxetine Dosing In The Treatment Of Women With Premenstrual Dysphoria
Hypnotics (not specified)
– Pharmacokinetics and Drug Interactions of the Sedative Hypnotics
Indinavir
– A Pharmacokinetic Drug-Drug Interaction Study of Venlafaxine and Indinavir
Inositol
– Inositol, Lithium, and the Brain
Isopropanol
Isotretinoin
Lamotrigine
Levomepromazine
– A Case of Stuttering During Treatment with Levomepromazine
– Catatonia and CPK Elevation in Neurosyphilis: Role of Plural Pharmacodynamic Mechanisms
Lithium
– Lithium-Induced Nephropathies
– Pulmonary Hypertension During Lithium Therapy: Clinical Case Study
MAOIs
– Monoamine Oxidase Inhibitors: A New Generation
MDD (Major Depressive Disorder)
– Major Depressive Disorder Following Dermatomyositis: A Case Linking Depression with Inflammation
Mementine
Metoclopramide
– Akathisia, Panic, Agoraphobia, and Major Depression Following Brief Exposure to Metoclopramide
Migraine (not specified)
Migraine, Serotonin, And The Mind-Body Dilemma
Nonpharmacologic Treatment Of Migraine
Symptomatic Pharmacotherapy Of Migraine
Migraine: The Interface Of Psychiatry And Neurology?
Mirtazapine
Moclobemide
– A Preliminary Open-Label Study of Moclobemide Treatment of Pain Disorder
Naltrexone
– A Systematic Review of Augmentation Strategies for Patients with Major Depressive Disorder
Nefazodone
Nitric Oxide
– Nitric Oxide, Stress, and Depression
NSAIDs
Obesity, Drug Induced
– The Effect of a Novel Dietary Intervention on Weight Loss in Psychotropic Drug-Induced Obesity
Olanzapine
– Efficacy of Olanzapine and Risperidone in Schizophrenia: A Randomized Double-Blind Crossover Design
– Disturbed Glucose Metabolism Among Patients Taking Olanzapine and Typical Antipsychotics
– Switching Antipsychotic Drugs: A Pharmacokinetic, Pharmacodynamic, and Practical Perspective
– Neuroleptic Malignant Syndrome Due to Olanzapine
Omega-3 Fatty Acids
– Efficacy of Omega-3 Fatty Acids in Mood Disorders – A Systematic Review and Metaanalysis
Orlistat
– Psychotropic Drug-Induced Weight Gain Alleviated with Orlistat: A Case Series
Paliperidone
– Paliperidone Palmitate Treatment In Outpatient Care Setting: A Naturalistic Study
– Long-Acting Injectable Paliperidone Palmitate: A Review Of Efficacy And Safety
Panic Disorder (not specified)
– Management of Treatment-Refractory Panic Disorder
Panic Disorder During Pregnancy
Paroxetine
– Paroxetine—The Antidepressant From Hell? Probably Not, But Caution Required
– Brief Report: Paroxetine in Younger and Adult Individuals at High Risk for Suicide
– A Randomized Controlled Trial of Paroxetine for Noncardiac Chest Pain
– Neuropharmacology of Paroxetine
– Pharmacokinetics, Drug Interactions, and Tolerability of Paroxetine and Paroxetine CR
– Paroxetine Treatment of Major Depressive Disorder
– Treatment of Panic Disorder: Focus on Paroxetine
– Paroxetine Treatment of Generalized Anxiety Disorder
– Treatment of Posttraumatic Stress Disorder: The Impact of Paroxetine
– Obsessive-Compulsive Disorder: Implications of the Efficacy of an SSRI, Paroxetine
– Advances in Recognition and Treatment of Social Anxiety Disorder: A 10-Year Retrospective
– Paroxetine Use in Medically Ill Patients
– Paroxetine Treatment of Depression in Late Life
– Paroxetine Treatment of Mood Disorders in Women: Premenstrual Dysphoric Disorder and Hot Flashes
– Clinical Management of Perinatal Depression: Focus on Paroxetine
– Paroxetine Treatment of Mood and Anxiety Disorders in Children and Adolescents
– Efficacy and Tolerability of Controlled-Release Paroxetine
Placebo (not specified)
– Suicide Risk Analysis Among Patients Assigned to Psychotropics and Placebo
PMDD (Premenstrual Dysphoric Disorder)
– An Interesting Presentation About Cyclical Menstrual Psychosis with an Updated Review of Literature
Prednisone
– Drug Dependence Involving Prednisone:Two Cases and a Review of the Literature
Pseudoephedrine
Psychopharmacology (not specified)
– Evidence-Based Decision-Making in Psychopharmacology
– An Evidence-Based Medicine Approach to Combined Treatment for ADHD in Children and Adolescents
– The Psychopharmacology of Fibromyalgia: A Drug Development Perspective
– Special Issues in the Psychopharmacological Management of Hispanic Americans
Pharmacologic Management Of Attention-Deficit/Hyperactivity Disorder
Psychotherapy (not specified)
Efficacy And Cost-Effectiveness Of Group Psychotherapy For Patients With Cancer
Movement Toward Evidence-Based Psychotherapies
Psychotropics – Dosing – New
– NEWLY UPDATED – The Black Book of Psychotropic Dosing and Monitoring – 2018
Ramelteon
– Ramelteon for Insomnia Related to Attention-Deficit/Hyperactivity Disorder (ADHD)
Reference Guides
– 2018 Update: Dosing and Monitoring: Children and Adolescents
– 2018 Update: The Black Book of Psychotropic Dosing and Monitoring
Risperidone
– Risperidone Induced Isolated Thrombocytopenia: A Rare Adverse Event
– Does Risperidone Improve Hyperacusia in Children with Autism?
– Long Acting Risperidone in an Adolescent with Conduct Disorder: A Case Report
– Does Risperidone Improve Hyperacusia in Children with Autism?
– Risperidone Induced Ventricular Tachycardia
– Long-Acting Injectable Risperidone in the Treatment of Schizophrenia in Special Patient Populations
– Efficacy of Olanzapine and Risperidone in Schizophrenia: A Randomized Double-Blind Crossover Design
– Risperidone in the Management of Psychiatric and Neurodegenerative Disease in the Elderly: An Update
– Risperidone: Review Of Its Therapeutic Utility In Depression
Schizophrenia (not specified)
– Rating Scales And Safety Measurements In Bipolar Disorder And Schizophrenia – A Reference Guide
– Signal Detection and Placebo Response in Schizophrenia: Parallels with Depression
– Paroxysmal Perceptual Alteration: Drug-Induced Phenomenon or Schizophrenic Psychopathology?
– Treatment Target in Schizophrenia: A Critical Review and a Clinical Suggestion
– Do Antipsychotic Drugs Influence Suicidal Behavior in Schizophrenia?
Pharmacologic Treatment Of Schizophrenia
Genetics Of Schizophrenia: Recent Advances
Neuropsychiatric Update: Neuroimaging Schizophrenia
Ethical Issues In Schizophrenia: Considerations For Treatment And Research
–Sex Differences In Antipsychotic Related Metabolic Functioning In Schizophrenia Spectrum Disorders
Selegiline
Sertraline
Sleep Disorders (not specified)
Sleep Disorders Centers—Function, Structure, And Economics
Shiftwork, Circadian Disruption, And Consequences
Recent Advances In The Understanding And Treatment Of Narcolepsy
Comorbidity Of Insomnia With Medical And Psychiatric Disorders
SSRIs/SNRIs (not specified)
– Are SNRIs More Effective than SSRIs? A Review of the Current State of the Controversy
– Can Serotonin and Fluoxetine Levels in Plasma and Platelets Predict Clinical Response in Depression?
St. John’s Wort
Stimulants (not specified)
– Photophobia and Methylphenidate
Suicide Prevention (not specified)
The Economic Burden of Suicide In The United States
Acute Vs Chronic Risk Factors For Suicide— Treatment Implications
Tiagabine
– The Use of Tiagabine Augmentation for Treatment-Resistant Anxiety Disorders: A Case Series
Transcranial Magnetic Stimulation (TMS)
– A Meta-analysis of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression
Translational Neuroscience
– Magnetic Resonance Spectroscopy: Neurochemistry and Treatment Effects in Affective Disorders
– Role of Central Melanocortin Signaling in Eating Disorders
– Bioelectrical Modulators and the Cell Membrane in Psychiatric Medicine
– Corticosteroid Receptors: A Dynamic Interplay Between Protein Folding and Homeostatic Control
Tranylcypromine
– Effects of Tranylcypromine on the Sleep of Patients with Anergic Bipolar Depression
Trazadone
Tryptophan
– Tryptophan Depletion, Serotonin, and Depression: Where Do We Stand?
Valbenazine
– Efficacy Of Valbenazine In Treating Subjects With Tardive Dyskinesia And Mood Disorder
Valproic Acid
– Valproic Acid And Hepatic Steatosis: A Possible Link? About A Case Report
Genomics.
– Valproate Use in Neuropsychiatric Disorders in the Elderly
– Divalproex in the Treatment of Migraine
– The Use of Divalproex in the Treatment of Addictive Disorders
– Divalproex in the Treatment of Bipolar Disorder
– The Efficacy of Divalproex for Partial Epilepsies
– Pharmacokinetics, Drug Interactions, and Tolerability of Valproate
– The History of Valproate in Clinical Neuroscience
Venlafaxine and Venlafaxine ER
– A Pharmacokinetic Drug-Drug Interaction Study of Venlafaxine and Indinavir
Vilazodone
Vortioxetine
– Effective Vortioxetine Dose Varies with Extent of Antidepressant Use Across Countries
Ziprasidone
– Ziprasidone Augmentation In An Adolescent With Obsessive Compulsive Disorder: A Case Report.
– Ziprasidone Induced Tardive Cervical Dystonia
– The Effect of Food on the Absorption of Oral Ziprasidone
– Ziprasidone and the QTc Interval: Pharmacokinetic and Pharmacodynamic Considerations
Zonisamide
– Zonisamide for Bipolar Depression: A Randomized, Double Blind, Placebo-Controlled, Adjunctive Trial