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Psychopharmacology Bulletin All Volumes & Issues VOL 41 No. 4 REVAMP – Research...
ORIGINAL RESEARCH

REVAMP – Research Evaluating the Value of Augmenting Medication with Psychotherapy: Rationale and Design

Psychopharmacology Bulletin 41(4) , 2008/11/10

Abstract

This report presents the rationale, design, and baseline sample characteristics for the REVAMP study. This project is a multisite clinical trial designed to evaluate the efficacy of augmenting state-of-the-art pharmacotherapy with psychotherapy in chronically depressed patients who fail to respond or respond incompletely to an initial trial of antidepressant medication. Background: Chronic forms of major depression disorder (cMDD) are longitudinally continuous forms of major depressive disorder (MDD), and may account for a significant portion of the societal burden of disease associated with MDD. Antidepressant medications and depression-focused psychotherapies have been shown to be effective for cMDD, though the majority fail to achieve remission following an acute course of treatment. There is a pressing need to evaluate whether the outcomes obtained from a well implemented medication algorithm combined with depression-focused psychotherapy can significantly enhance outcomes for cMDD. Rationale: Although there is evidence for the effectiveness of depression-focused psychotherapy for the treatment of cMDD, this is the first prospective, randomized, controlled trial investigating.

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How to Cite

Madhukar H. Trivedi, James H. Kocsis, Michael E. Thase, David W. Morris, Stephen R. Wisniewski, Andrew C. Leon, Alan J. Gelenberg, Daniel N. Klein, George Niederehe, Alan F. Schatzberg, Philip T. Ninan, Martin B. Keller. REVAMP – Research Evaluating the Value of Augmenting Medication with Psychotherapy: Rationale and Design. Psychopharmacology Bulletin. 2008/11/10; 41(4).