VOL 56 No. 1

ORIGINAL RESEARCH

A Prospective 12-week Randomized Controlled Trial of Remotely-Delivered Customized Adherence Enhancement for Poorly Adherent Individuals with Schizophrenia vs Enhanced Treatment as Usual

Martha Sajatovic, Jennifer B. Levin, Gracie Howard-Griggs, Jessica Surdam, Jacqueline Krehel-Montgomery, Sakshi Priya, Nicole Fiorelli, Farren Briggs

Objective: This prospective 12-week randomized controlled trial tested an adherence promotion approach called Customized Adherence Enhancement in schizophrenia (CAE-S) vs. Enhanced Treatment as Usual (eTAU) in 36 poorly adherent individuals. Methods: Patients were randomized to...

Pages 8-27 Read Article

ORIGINAL RESEARCH

Glecaprevir/Pibrentasvir for Post Traumatic Stress Disorder

Bradley V. Watts, Jessica E. Hoyt, Krista D. Disano, Crystal M. Noller, Luke Rozema, Danielle M. Foster, Matthew Vincenti, Brian Shiner

Objective: Posttraumatic Stress Disorder (PTSD) is a common condition with few effective medication treatments. Glecaprevir/Pibrentasvir (GLE/PIB), a treatment for hepatitis C virus (HCV) infection, demonstrated possible evidence of effectiveness for PTSD in an epidemiological study....

Pages 28-38 Read Article

ORIGINAL RESEARCH

Trends in Opioid Prescribing and Co-Prescription of Opioid Antagonists: A Retrospective Analysis over a 12-Month Period

Jamal Hasoon, Ahmed Abdalla, Giuliano Lo Bianco, Christopher L. Robinson

Background: Opioid prescribing practices have come under increased scrutiny due to the ongoing opioid crisis, with efforts focusing on harm reduction strategies such as co-prescription of opioid antagonists. This study analyzes opioid prescribing trends and...

Pages 39-47 Read Article

ORIGINAL RESEARCH

Differences in the Prevalence of Use and Dosage of Psychotropic Drugs by Smoking Status in Inpatient and Outpatient: An Observational, Analytical, Cross-Sectional Study

Pedro Damian Gargoloff, Martín A. Urtasun, Raul Riveros, Iván Omar Moreno Frade, Martín Cañás

Objective: To estimate the association between tobacco use and the prevalence of psychotropic medication use and prescribed dosage among inpatients and outpatients with severe mental disorders treated at a neuropsychiatric hospital. Methods: Observational, cross-sectional, analytical...

Pages 48-63 Read Article

ORIGINAL RESEARCH

Tramadol Utilization Patterns: A One-Year Retrospective Review

Jamal Hasoon, Anvinh Nguyen, Ivan Urits, Omar Viswanath

Background: Tramadol is a widely used analgesic with a unique dual mechanism of action, combining weak μ-opioid receptor agonism with inhibition of norepinephrine and serotonin reuptake. It is frequently prescribed for various acute and chronic...

Pages 64-70 Read Article

ORIGINAL RESEARCH

Risk of Obesity in Patients Treated with Clozapine or Olanzapine: A Simple, Clinically Useful Prediction Tool

Roberto Lozano, Carina Bona

Background: Clozapine and olanzapine are associated with clinically relevant weight gain and metabolic risk. Objective: To compare the risk of obesity (BMI ⩾ 30) between clozapine and olanzapine and to develop a parsimonious prediction model...

Pages 71-81 Read Article

ORIGINAL RESEARCH

Personalizing Treatment for Acute Alcoholic Hallucinosis: Clinical Utility of Integrated Pharmacogenetic Testing, Metabolic Phenotyping, and microRNA Biomarkers

Valentin Skryabin, Anton Masyakin, Sergei Pozdniakov, Igor Shatokhin, Svetlana Sokolova, Valentina Ivanchenko, Polina Makartseva

Background: Acute alcoholic hallucinosis (ICD-10 F10.52) necessitates urgent antipsychotic treatment but carries high risks of adverse drug reactions (ADRs). While pharmacogenetic clinical decision support systems (CDSS) show promise, their utility is limited by static genotyping...

Pages 82-91 Read Article

GENERAL PSYCHIATRY

A Pilot Study Exploring the Impact of Pro Re Nata Medication Utilization on Aggression in Forensic Psychiatric Patients

Gabrielle Morgan, O. Greg Deardorff, Raja Hussain, Alexandria Choate, Manfredo Flores Cruz, Roger W. Sommi, Niels C. Beck

Objective: To analyze patterns of pro re nata (PRN) medication utilization during the seven-day periods preceding and following aggressive incidents in a forensic setting, including both psychotropic and somatic agents, to identify trends in use...

Pages 92-97 Read Article

REVIEW ARTICLE

Lorazepam-Assisted Interview in Clinical Psychiatry: A Narrative Review of Current Evidence and Research Gaps

Omar Afroz, Raja Babu Ramawat, Romil Saini, Siddharth Sarkar

Introduction: Drug-assisted interviews have been used in psychiatry for about a century. The use of barbiturates for this purpose has declined, and the use of lorazepam has gained popularity over time for conducting drug-assisted interviews,...

Pages 98-111 Read Article

REVIEW ARTICLE

Emerging Innovations in Third- and Fourth-Generation Antipsychotics: Mechanistic Advances and Clinical Implications

Adel Awadh Baeissa

Over the last twenty years, the development of antipsychotic medications has progressed from simple dopamine receptor antagonism to more complex, multi-receptor strategies. This evolution reflects an effort to improve therapeutic effectiveness, reduce side effects, and...

Pages 112-125 Read Article

COMPLICATED CASE HISTORY

Lamotrigine-Induced DRESS Syndrome with Myelosuppression in a Patient with Bipolar Disorder: Case Report

Marlene Kelbrick, Feras Ali Mustafa, Helen Wilson, Lynn Nyadzayo, David Ibrahim, Gabriela Paduret

Lamotrigine-induced DRESS syndrome is a potentially fatal drug reaction with variable clinical presentation and complications requiring early recognition and rapid response. Psychopharmacology Bulletin. 2026;56(1):126–130.

Pages 126-130 Read Article

COMPLICATED CASE HISTORY

Multisystem Sequelae of Chronic Diphenhydramine Misuse in an Adolescent: A Case Highlighting the Importance of Comprehensive History-Taking

Justin M. Howe, Jay Vora, Abhishek Reddy

Background: Diphenhydramine, an over-the-counter antihistamine, is increasingly misused by adolescents for its sedative and hallucinogenic effects. Despite its accessibility and perceived safety, chronic misuse poses serious risks, including neurologic, psychiatric, and gastrointestinal complications, especially in...

Pages 131-136 Read Article

COMPLICATED CASE HISTORY

The Intersections of Fetal Alcohol Syndrome with Autism Spectrum Disorder and Mood Dysregulation: A Rare Case of Behavioral Complexity

Parsa Khaksar, Anuradha Reddy

This case report presents a complex psychiatric profile of a 19-year-old female with diagnoses of Fetal Alcohol Syndrome (FAS), Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), mild intellectual disability, and mood dysregulation, complicated by trauma...

Pages 137-141 Read Article

COMPLICATED CASE HISTORY

The Intersection of Gender Dysphoria (GD) and Autism Spectrum Disorder (ASD): A Case Series

Trishna Sharma, Anuradha Reddy

Over the past two decades, there has been a growing interest in the co-occurrence of gender dysphoria (GD) and autism spectrum disorder (ASD). This case series will examine five patients from our clinic population who...

Pages 142-161 Read Article

COMPLICATED CASE HISTORY

The Use of Lorazepam for Acute Episodes in a Patient with Kleine-Levin Syndrome: A Longitudinal Case Report

Michael Hamper, Michael Rancurello

Kleine-Levin Syndrome (KLS) is a rare, neurological disorder characterized by episodes of hypersomnia, cognitive impairment, and behavioral abnormalities. The etiology of KLS remains unclear, and treatment responses are highly variable. This report describes a 22-year...

Pages 162-169 Read Article