We are frequently consulted by patients with treatment resistant depression (TRD).Reference Fogelson and Leuchter1 Many of these patients have never met criteria for a manic episode so they are not diagnosed with bipolar disorder (BPD). Consequently, they have undergone trials of antidepressants with or without augmentation therapies without success.Reference Perlis, Uher [...]
Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as a gold standard, researchers, Turner, Cipriani, Furukawa, et al. previously found that the published literature inflated the apparent efficacy of antidepressant drugs. [...]
On individuals with major depressive disorder (MDD), particularly those who experience suicidal thinking, levels of translocator protein (TSPO), a marker of microglial inflammation, are increased, new research shows. Investigators from the University of Manchester, United Kingdom, found significantly higher levels of TSPO in patients with MDD than in healthy control [...]
The number of retirement-age Americans taking at least three psychiatric drugs more than doubled between 2004 and 2013, even though almost half of them had no mental health diagnosis on record, according to a new study published in JAMA Internal Medicine and reported in today's New York Times. The new [...]
Charles Marmar, a 71-year-old psychiatrist in New York, has spent his career studying post traumatic stress disorder, which has symptoms such as sleep disruption and vivid flashbacks of the traumatic experience. PTSD is often associated with war: Between 11% and 20% of veterans who served in Iraq and Afghanistan have [...]