VOL 56 No. 3

Background Approximately 30% of patients treated for major depressive disorder develop treatment-resistant depression (TRD). The STAR*D study demonstrated remission rates decline progressively with each antidepressant failure (37%, 31%, 14%, and 13%, respectively). A single-day individualized...

Objective Inflammation has been proposed as a possible mechanism and treatment target for posttraumatic stress disorder (PTSD), but traditional methods for measuring it are performed infrequently in clinical practice. The present study sought to determine...

Introduction This study examines how inpatients with catatonia responded when treated with or without antipsychotic medications. It employs two metrics to account for both the catatonic symptoms and the more traditionally psychotic symptoms. Length of...

Background Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder associated with persistent functional impairment across the lifespan. Although several pharmacological treatments are available, their clinical utility is often limited by tolerability concerns, heterogeneous efficacy, and...

Background Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics that can cause significant functional impairment. Deutetrabenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor, has been evaluated in randomized controlled trials...

Major Depressive Disorder (MDD) represents the classically described episodic depression, with varying degrees of severity and recurrence. With a lifetime prevalence close to 20%, the condition represents a leading cause of disability worldwide. Pharmacotherapy is...

The American medical landscape is currently defined by a profound paradox. While the ongoing opioid crisis, characterized by a rise in synthetic illicit opioids continues to ravage communities, our primary pharmacological defense for both opioid...

Background Traumatic brain injury (TBI) is associated with a range of neuropsychiatric sequelae, including secondary psychotic disorders. Delusional syndromes are a prominent and clinically significant manifestation, often classified as Psychotic Disorder Due to Another Medical...

Background Antipsychotic medications are associated with increased cardiovascular morbidity and mortality in patients with serious mental illness (SMI). Clozapine-induced myocarditis and cardiomyopathy are well established; however, emerging pharmacovigilance and observational data suggest that cardiotoxic risk...

Aims To compare the efficacy and safety of electroconvulsive therapy (ECT) and ketamine infusion (KET-IFU) in routine care for patients with bipolar I or II depression (BPD). Methods Electronic medical records of patients who received...

Abrupt discontinuation of clozapine can result in serious and potentially life-threatening psychiatric and physical complications, including psychotic rebound, increased risk of suicide, catatonia, cholinergic rebound, and autonomic instability. Although exceedingly rare, the literature contains case...

Adolescent bipolar disorder (BD) is frequently accompanied by persistent sleep disturbances and depressive episodes that are resistant to standard treatments. Conventional antidepressants carry a risk of inducing mania or rapid cycling, particularly in younger patients....

We report the case of a 27-year-old male who developed elevated liver enzymes during treatment with low-dose mirtazapine for insomnia. Liver function normalized after discontinuation of the drug, supporting a probable drug-induced liver injury (DILI)....

Escitalopram-induced dystonia is a rare but clinically important occurrence. Clinicians should have a high index of suspicion in order to intervene early and improve symptoms.

This case of a 10-year-old girl herein presented is one of the earliest to report safe and effective use of cariprazine, a metabolic-friendly agent, targeting the behavioral facets in ASD. This might open new treatment...

Eugeroics are a distinct, yet heterogeneous group of psychotropic agents that differ from classical stimulants, are less activating, of less abuse potential, sorely clinically underutilized, and have an attractive pharmacological portfolio speaking to the idea...