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Psychopharmacology Bulletin › All Volumes & Issues › VOL 50 No. 4
PSYCHOPHARMACOLOGY BULLETIN

VOL 50 No. 4

Articles in This Issue

ORIGINAL RESEARCH

Patient Response Trajectories in Major Depressive Disorder

Klaus G. Larsen, Sidney H. Kennedy, Elin Heldbo Reines, Michael E. Thase
Objective To investigate whether the efficacy of antidepressants can be understood in terms of patient response-trajectory classes. Experimental Design Patient-level data were analysed from 1357 adults with MDD randomised to either escitalopram 20 mg/day (...
Pages 8-28 Read Article
GENERAL PSYCHIATRY

Lumateperone for the Treatment of Schizophrenia

Amber Edinoff, Natalie Wu, Charles deBoisblanc, Catherine Olivia Feltner, Mariah Norder, Vesela Tzoneva, Adam M. Kaye, Elyse M. Cornett, Alan D. Kaye, Omar Viswanath, Ivan Urits
Introduction Schizophrenia is a severe psychotic disorder that is diagnosed by the presence of hallucinations or delusions along with disorganized speech, disorganized thought, or negative symptoms that are present for at least six months. Roughly...
Pages 32-59 Read Article
COMPLICATED CASE HISTORY

Asenapine Transdermal Patch for the Management of Schizophrenia

Maxine Zhou, Sahar Derakhshanian, Alexander Rath, Sarah Bertrand, Caroline DeGraw, Rachel Barlow, Aja Menard, Adam M. Kaye, Jamal Hasoon, Elyse M. Cornett, Alan D. Kaye, Omar Viswanath, Ivan Urits
Purpose of Review This is a comprehensive review of the literature regarding the use of asenapine for the treatment of schizophrenia (SZ) in adults. It covers an introduction, epidemiology, risk factors, pathophysiology, and current treatment...
Pages 60-82 Read Article
GENERAL PSYCHIATRY

Cariprazine to Treat Schizophrenia and Bipolar Disorder in Adults

Amber Edinoff, Miriam T. Ruoff, Yahya T. Ghaffar, Arthur Rezayev, Devanshi Jani, Adam M. Kaye, Elyse M. Cornett, Alan D. Kaye, Omar Viswanath, Ivan Urits
Purpose of Review Antipsychotics are the standard of care when it comes to the treatment of Schizophrenia, and they are often used in Bipolar as well. Their use can come with adverse effects such as...
Pages 83-117 Read Article
REVIEW ARTICLE

Efficacy and Tolerability of Lamotrigine in Borderline Personality Disorder: A Systematic Review and Meta-Analysis

Mehak Pahwa, Nicolas A Nuñez, Boney Joseph, Ashok Seshadri, Danielle J Gerberi, Mark A Frye, Balwinder Singh
Background Patients with Borderline Personality Disorder (BPD) have a high prevalence of mood disorders. Lamotrigine (LAM) is often used as an off-label therapeutic option for BPD. We aimed to conduct a systematic review and meta-analysis...
Pages 118-136 Read Article
REVIEW ARTICLE

An Update on the Efficacy and Tolerability of Oral Ketamine for Major Depression: A Systematic Review and Meta-Analysis

Nicolas A. Nuñez, Boney Joseph, Mehak Pahwa, Ashok Seshadri, Larry J. Prokop, Simon Kung, Kathryn M. Schak, Jennifer L. Vande Voort, Mark A. Frye, Balwinder Singh
Background Intravenous Ketamine has shown robust antidepressant efficacy although other routes of administration are currently needed. We conducted a systematic review and meta-analysis of studies evaluating the efficacy and tolerability of oral ketamine for depression....
Pages 137-163 Read Article