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Psychopharmacology Bulletin › All Volumes & Issues › VOL 42 No. 4
PSYCHOPHARMACOLOGY BULLETIN

VOL 42 No. 4

Articles in This Issue

ORIGINAL RESEARCH

The Efficacy and Tolerability of Once-daily Controlled-release Trazodone for Depressed Mood, Anxiety, Insomnia, and Suicidality in Major Depressive Disorder

David V. Sheehan, Anna Rozova, E. Roderich Gossen, Michael Gibertini
Trazodone Contramid® once-a-day (TzCOAD) is a reformulation of trazodone hydrochloride that controls the release of trazodone over 24 hours. A standard effect size analysis (Cohen’s d) determined which items of the 17-item Hamilton Depression Rating...
Pages 5-22 Read Article
ORIGINAL RESEARCH

Early Predictors of Weight Gain Risk During Treatment with Olanzapine:Analysis of Pooled Data from 58 Clinical Trials

Ilya Lipkovich, Jennie G. Jacobson, Cathy Caldwell, Vicki Poole Hoffmann, Ludmila Kryzhanovskaya, Charles M. Beasley
This analysis evaluated the usefulness of different predictors in identifying patient risk of substantial weight gain (SWG) during olanzapine treatment. Data were from 58 studies with 3826 patients diagnosed with schizophrenia, schizophrenia spectrum disorders, bipolar...
Pages 23-39 Read Article
COMPLICATED CASE HISTORIES

Catatonia and CPK Elevation in Neurosyphilis: Role of Plural Pharmacodynamic Mechanisms

Edward C. Lauterbach, Byron K. Norris, W. Grady Carter, Samuel D. Shillcutt
Objectives: To report catatonia in neurosyphilis with elevated creatine phosphokinase (CPK) and to understand the pharmacodynamics of catatonia. Experimental design: Case report. Principal Observations: We encountered catatonia in a man with neurosyphilis after increasing aripiprazole...
Pages 53-63 Read Article
COMPLICATED CASE HISTORIES

Ziprasidone Induced Tardive Cervical Dystonia

Ayse Kutlu, Senem Dündar, Nur S. Altun, Faik Budak
Fifty years old female patient used 80 mg/day ziprasidone for 4 months after diagnosed as atypical depression. After 4 months of ziprasidone treatment, involuntary movements appeared in her neck region. Ziprasidone was stopped in by...
Pages 64-68 Read Article
COMPLICATED CASE HISTORIES

Amisulpride for Clozapine Induced Sialorrhea

Ashish Aggarwal, Dinesh Dutt Sharma
Clozapine is an atypical and novel antipsychotic medication useful for patients with schizophrenia who are refractory to treatment. Its use is often associated with troublesome side effects like sialorrhea, sedation, weight gain, enuresis, dizziness, besides...
Pages 69-71 Read Article