Psychopharmacology Bulletin VOL 42 No. 2

ORIGINAL RESEARCH

Clinical Significance of Transcranial Magnetic Stimulation (TMS) in the Treatment of Pharmacoresistant Depression: Synthesis of Recent Data

Mark A. Demitrack, Michael E.Thase

Transcranial magnetic stimulation (TMS) is a novel treatment for patients with major depressive disorder. Although clearly safer and better tolerated than many other pharmacotherapeutic options or electroconvulsive therapy, questions have persisted about the magnitude of...

Pages 5-8 Read Article

ORIGINAL RESEARCH

Statistical Strategies for Randomized Controlled Clinical Trials to Detect Differential Onset of Action

Andrew C. Leon

Designing a randomized controlled clinical trial to detect differential onset of action of treatments for mood and anxiety disorders poses several challenges. The definition of onset of action must embrace both the degree of symptom...

Pages 39-40 Read Article

DRUG INTERACTIONS

Desvenlafaxine and Venlafaxine Exert Minimal In Vitro Inhibition of Human Cytochrome P450 and P-Glycoprotein Activities

Aram Oganesian, Adam D. Shilling, Ruth Young-Sciame, Judy Tran, Adiba Watanyar, Farooq Azam, John Kao, Louis Leung

Objective: Identification of potential pharmacokinetic drug-drug interactions is an important step in clinical drug development. We assessed and compared the drug-drug interaction potential of desvenlafaxine and venlafaxine, based on their inhibitory potency on human cytochrome...

Pages 47-48 Read Article

EVIDENCE-BASED MEDICINE

Revisiting the Effectiveness of Standard Antidepressants in Bipolar Disorder: Are Monoamine Oxidase Inhibitors Superior?

Alan G. Mallinger, Ellen Frank, Michael E.Thase, Michelle M. Barwell, Nancy DiazGranados, David A. Luckenbaugh, David J. Kupfer

The role of antidepressants in treating bipolar disorder is controversial, and the comparative effectiveness of specific drugs is insufficiently studied. We report here a comparison of monoamine oxidase inhibitors (MAOIs) with the serotonin reuptake inhibitor...

Pages 64-65 Read Article

BRAIN IMAGING

Recent-Onset Schizophrenia and Adolescent Cannabis Use: MRI Evidence for Structural Hyperconnectivity?

Bart D. Peters, Lieuwe de Haan, Erik-Jan Vlieger, Charles B. Majoie, Gerard J. den Heeten, Don H. Linszen

There is growing evidence that brain white matter abnormalities are implicated in the pathophysiology of schizophrenia. Cannabis use is an independent risk factor for schizophrenia. We tested the hypothesis that cannabis use during early adolescence...

Pages 75-76 Read Article

COMPLICATED CASE HISTORIES

Hypomania Induced by Escitalopram: 2 Case Reports

Ravi C. Sharma

Two cases, one of recurrent depression and another of major depressive disorder with hypertension, switched to hypomania while on escitalopram. Both patients achieved remission with atypical antipsychotics and divalproex. The implications of diagnosis and treatment...

Pages 89-91 Read Article

VOL 42 No. 2

Articles in This Issue

Clinical Significance of Transcranial Magnetic Stimulation (TMS) in the Treatment of Pharmacoresistant Depression: Synthesis of Recent Data

Statistical Strategies for Randomized Controlled Clinical Trials to Detect Differential Onset of Action

Desvenlafaxine and Venlafaxine Exert Minimal In Vitro Inhibition of Human Cytochrome P450 and P-Glycoprotein Activities

Revisiting the Effectiveness of Standard Antidepressants in Bipolar Disorder: Are Monoamine Oxidase Inhibitors Superior?

Recent-Onset Schizophrenia and Adolescent Cannabis Use: MRI Evidence for Structural Hyperconnectivity?

Hypomania Induced by Escitalopram: 2 Case Reports

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