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Psychopharmacology Bulletin › All Volumes & Issues › VOL 40 No. 4
PSYCHOPHARMACOLOGY BULLETIN

VOL 40 No. 4

Articles in This Issue

REVIEW ART I C L E

Neuropsychiatric Update: Neuroimaging Schizophrenia

Shawn J. Kile, MD
Neuroimaging has revitalized the quest for the neurobiology of schizophrenia. The various neuroimaging modalities used in research are described including CT, MRI, PET, SPECT, fMRI, and DTI. Prominent and consistent neuroanatomical findings in the neuroimaging...
Pages 4-11 Read Article
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Evidence-Based Treatment of Psychiatric Disorders with Comorbid Medical Illnesses: The Need for Large Simple Clinical Trials

Warren D.Taylor, MD, P. Murali Doraiswamy, M.B.,B.S., and K. Ranga R. Krishnan, M.B.,B.S
When discussing psychiatric illnesses in the elderly, one cannot ignore coexisting medical problems. With aging, there is a rapid increase in the prevalence of medical disorders including cancer, Alzheimer’s disease, stroke, heart disease, and arthritis....
Pages 5-11 Read Article
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Migraine And The Limbic System: Closing The Circle

C. Philip O’Carroll, MD
A tremendous gap still exists between the disciplines of psychiatry and neurology, viewed as the study of the mind, and the brain, respectively. While functional neuroimaging has served to blur this separation, many still consider...
Pages 12-23 Read Article
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Understanding The Fibromyalgia Syndrome

Srinivas G. Rao, MD, PhD, Judith F. Gendreau, MD, and Jay D. Kranzler, MD, PhD
The fibromyalgia syndrome (FMS) is the most frequent cause of chronic, widespread pain. This review, which is targeted at the psychiatry and psychopharmacology communities, summarizes the state-of-the-art as it relates to both the pathophysiology and...
Pages 24-66 Read Article
COMMENTARY

Invited Commentary: Understanding the Fibromyalgia Syndrome

Jon Russell, MD, PhD, and Christopher J. Wohlberg, MD, PhD
In this edition, Rao et al. have updated their previous review of the psychopharmacology of fibromyalgia. Indeed, much has happened since the publication by Kranzler et al., including the approval, by the US Food and...
Pages 68-73 Read Article
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Cognitive Behavioral Approaches to the Treatment of Pain

Sandra J. Waters, PhD, Daphne C. McKee, PhD, and Francis J. Keefe, PhD
How can cognitive-behavioral therapy benefit patients with persistent pain? The purpose of this review is to provide an overview of cognitive-behavioral treatment approaches to persistent pain. The review is divided into four sections. In the...
Pages 74-88 Read Article
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Pharmacotherapy of Neuropsychiatric Syndromes in Neurologic Disorders: Definitional and Regulatory Aspects

Jeffrey L. Cummings, MD and Dilip V. Jeste, MD
Background: Neuropsychiatric symptoms are common in many neurologic diseases. Psychosis, depression, agitation, anxiety, irritability, and apathy occur in degenerative, traumatic, vascular, and demyelinating brain diseases. Design: Regulatory policies regarding approval of psychotropic agents for treatment...
Pages 89-98 Read Article
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Genetics and Its Use in Alzheimer’s Disease

Joseph H. Lee, DRPH and Richard Mayeux, MD, MSC
How useful is genetics to a clinician who treats patients with Alzheimer’s disease (AD)? Even though much has been learned about the genetics of AD, given the current state of knowledge, the application of genetics...
Pages 132-144 Read Article
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Genetics of Schizophrenia: Recent Advances

Amy Eisener, BS, Michele T. Pato, MD, Helena Medeiros, MSW, Celia Carvalho, MS, and Carlos N. Pato, MD
Genetic studies of schizophrenia have been fraught with challenges, yet molecular genetic and genomic methods remain essential to the discovery of the underlying biological mechanisms. Candidate genes and genome scan studies have played a significant...
Pages 168-177 Read Article
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Gender and Schizophrenia

Carla M. Canuso, MD and Gahan Pandina, PhD
What are the important gender differences seen in men and women with schizophrenia? Although schizophrenia affects men and women with equal frequency, the illness is expressed differently between the sexes. Women with schizophrenia tend to...
Pages 178-190 Read Article
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Primary Sexual Disorders: Recognition and Treatment

Paula L. Hensley, MD, and Carol K. Slonimski, PhD
Sexual dysfunction is a common complaint in women across different treatment settings and throughout the lifecycle. Defining normality in sexual response is extremely difficult and little data exists to guide the clinician encountering these complaints....
Pages 191-204 Read Article
REVIEW

Androgens and the Aging Male

Stuart N. Seidman, MD
In contrast to women, men do not experience a sudden cessation of gonadal function comparable to menopause. However, there is a progressive reduction in male hypothalamic-pituitary-gonadal (HPG) axis function: testosterone levels decline through both central...
Pages 203-218 Read Article