VOL 40 No. 1

ORIGINAL RESEARCH

Positron Tomographic Emission Study of Olfactory Induced Emotional Recall in Veterans with and without Combat-Related Post Traumatic Stress Disorder

Eric Vermetten, MD, PhD, Christian Schmahl, MD, Steven M. Southwick, MD, and J. Douglas Bremner, MD

Memory for odors is often associated with highly emotional experiences, and odors have long been noted by clinicians to be precipitants of trauma symptoms in posttraumatic stress disorder (PTSD). Primitive brain systems involved in fear...

Pages 8-32 Read Article

ORIGINAL RESEARCH

Treatment Characteristics and Illness Burden Among European Americans, African Americans, and Latinos in the First 2,000 Patients of the Systematic Treatment Enhancement Program for Bipolar Disorder

Jodi M. Gonzalez, PhD, Peter Thompson, MD, Michael Escamilla, MD, Mako Araga, MS, Vivek Singh, MD, Niamh Farrelly, MD, Michael E. Thase, MD, David J. Miklowitz, PhD, and Charles L. Bowden, MD

Across ethnicity/race, prevalence rates of bipolar disorder are similar. However, African Americans and Latinos may receive less specialty mental health treatment and different medications, and may be less adherent to treatment regimens than European American...

Pages 31-46 Read Article

ORIGINAL RESEARCH

Effect of Mirtazapine Orally Disintegrating Tablets on Health-Related Quality of Life in Elderly Depressed Patients with Comorbid Medical Disorders: A Pilot Study

Indira Varia, MD, Srimathi Venkataraman, MBBS, Caroline Hellegers, MA, Kenneth Gersing, MD, and P. Murali Doraiswamy, MD

There is a need for additional studies on the quality of life (QOL) of elderly depressed subjects with medical comorbidity. Method: We conducted a 10-week, open trial of mirtazapine orally disintegrating tablets in 16 elderly...

Pages 47-57 Read Article

ORIGINAL RESEARCH

Leptin and Leptin Receptor Gene Polymorphisms and Increases in Body Mass Index (BMI) from Olanzapine Treatment in Persons with Schizophrenia

Vicki L. Ellingrod, PharmD, BCPP, Jeffrey R. Bishop, PharmD, MS, Jessica Moline, BS, Ying-Chi Lin, MS, and Del D. Miller, PharmD, MD

Objective: The objective of the current investigation was to determine the relationship between polymorphisms of the leptin system (leptin gene and leptin receptor) and olanzapine-induced weight gain in persons with schizophrenia. Design: Pharmacogenetic association reanalysis...

Pages 57-62 Read Article

ORIGINAL RESEARCH

Citalopram Versus Amitriptyline in Elderly Depressed Patients with or without Mild Cognitive Dysfunction: A Danish Multicentre Trial in General Practice

Claus Rosenberg, MD, Lise Lauritzen, MD, Jørgen Brix, MD, Jørgen B. Jørgensen, MD, Palle Kofod, MD, and Liselotte Been Bayer

This double-blind, multicenter trial, carried out in general practice in Denmark, comprised 221 women and 70 men, aged 58–97 years, with major depression (with or without mild cognitive dysfunction) or dysthymia (DSM-III-R). Patients had a...

Pages 63-73 Read Article

ORIGINAL RESEARCH

Atypical Antipsychotics and Pituitary Neoplasms in the WHO Database

P. Murali Doraiswamy, MD, Gisela Schott, MD, MPH, Kristina Star, RN, Ralph Edwards, MD, and Bruno Mueller-Oerlinghausen, MD

Amisulpride and risperidone had among the highest Information Component (IC) scores for benign pituitary neoplasm: amisulpride (IC = 3.31, IC025 = 1.83, 5 reports) and risperidone (IC = 4.03, IC025 = 3.33, 19 reports), and...

Pages 74-76 Read Article

Drug–Drug Interactions Associated with Second-Generation Antipsychotics: Considerations for Clinicians and Patients

Robert R. Conley, MD, and Deanna L. Kelly, PharmD, BCPP

While not always clinically significant, patients with schizophrenia may be at risk for drug–drug interactions (DDIs) with second-generation antipsychotics. Second-generation antipsychotics are increasingly being used in a broader population of patients and, therefore, for those...

Pages 77-97 Read Article

EVIDENCE-BASED MEDICINE

Current Approaches to the Pharmacologic Treatment of Anxiety Disorders

David V. Sheehan, MD, MBA, and Kathy Harnett Sheehan, PhD

Despite their high prevalence, the anxiety disorders are underdiagnosed and undertreated. Benzodiazepines, once the first line of treatment, have been superseded by SSRIs as the treatment of choice. Preclinical studies, however, suggest that CRF antagonists...

Pages 98-109 Read Article

COMPLICATED CASE HISTORIES

Pulmonary Hypertension During Lithium Therapy: Clinical Case Study

M.E. Ceylan, MD, PharmD and M.H. Alpsan, MD

The authors presented a case of pulmonary hypertension during lithium therapy, in a patient who had been on lithium for six years. The patient developed pulmonary hypertension without any prior diagnosed cardiac or pulmonary disease....

Pages 110-112 Read Article

COMPLICATED CASE HISTORIES

Treatment Refractory Psychosis Remitted Upon Treatment with Continuous Positive Airway Pressure: A Case Report

Alina Karanti, MD and Mikael Landén, MD, PhD

Introduction: Patients refractory, or responding only partially, to antipsychotic drugs are common in clinical practice. Medical diseases can present with psychotic symptoms or add to a psychotic picture and should not be missed. We report...

Pages 113-117 Read Article

COMPLICATED CASE HISTORIES

Fibromylagia, Chronic Fatigue, and Adult Attention Deficit Hyperactivity Disorder in the Adult: A Case Study

Joel L. Young, MD and Judith C. Redmond, MA

Adult attention deficit hyperactivity disorder (ADHD) may share common features with fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS). In an outpatient psychiatric clinic, a number of adult patients who presented primarily with symptoms of...

Pages 118-118 Read Article