VOL 37 No. 3

EVIDENCE-BASED MEDICINE

An Evidence-Based Medicine Approach to Combined Treatment for ADHD in Children and Adolescents

Douglas G. Kondo, MD, Allan K. Chrisman, MD, and John S. March, MD, MPH

Psychiatrists need to update their skills to incorporate advances in psychiatric practice and to do so “at the bedside.” To this end, evidence-based medicine (EBM), which is widely used as an educational heuristic in other...

Pages 7-23 Read Article

EVIDENCE-BASED MEDICINE

Evidence-Based Decision-Making in Psychopharmacology

Ranga Krishnan, MB, ChB

When evaluating patients and making treatment decisions, physicians do not always have all the information necessary and may have to make judgments using limited information. This judgment is often intuitive in nature. The processes by...

Pages 24-28 Read Article

TRANSLATIONAL NEUROSCIENCE

IFN-Induced Depression: A Role for NSAIDs

Gregory M. Asnis, MD, Richard De La Garza II, PhD, Shari R. Kohn, PhD, John F. Reinus, MD, Margaret Henderson, MD, and Johar Shah, MD

Interferon-α (IFN) is widely used for the treatment of viral illnesses and other chronic diseases, though its usefulness is hampered by a problematic side-effect profile. In particular, IFN-α induces neuropsychiatric and neurotoxic side effects, including...

Pages 29-50 Read Article

TRANSLATIONAL NEUROSCIENCE

The Homer Family and the Signal Transduction System at Glutamatergic Postsynaptic Density: Potential Role in Behavior and Pharmacotherapy

Andrea de Bartolomeis, MD, PhD, and Felice Iasevoli, MD

The postsynaptic density (PSD) is an ultrastructural specialization of the glutamatergic excitatory synapses, located at the cytosolic surface of the postsynaptic membrane of dendritic spines. The PSD is a highly organized transductional machinery that tunes...

Pages 51-81 Read Article

TRANSLATIONAL NEUROSCIENCE

Acute Cortisol Administration Triggers Craving in Individuals with Cocaine Dependence

Igor Elman, MD, Scott E. Lukas, PhD, Katherine H. Karlsgodt, BA, Gregory P. Gasic, PhD, and Hans C. Breiter, MD

Stress is often mentioned as a factor in the development of drug abuse. Twelve cocaine-dependent individuals were administered a stress hormone, cortisol, along with cocaine and saline via intravenous boluses in a double-blind, counterbalanced fashion....

Pages 84-89 Read Article

GENERAL PSYCHOPHARMACOLOGY

Economic Impact of Olanzapine Plus Fluoxetine Combination Therapy Among Patients Treated for Depression: A Pilot Study

Patricia K. Corey-Lisle, PhD, RN, CS-P, Howard Birnbaum, PhD, Paul Greenberg, MA, MS, Maryna Marynchenko, BA, and Sanjay Dube, MD

Individuals with treatment-resistant depression (TRD) utilize more health care services and are significantly more costly. Drug treatments for TRD may include concomitant administration of multiple antidepressants or augmentation with mood stabilizers or antipsychotic agents. An...

Pages 90-98 Read Article

GENERAL PSYCHOPHARMACOLOGY

Disturbed Glucose Metabolism Among Patients Taking Olanzapine and Typical Antipsychotics

Boadie W. Dunlop, MD, Maya Sternberg, PhD, Lawrence S. Phillips, MD, Judy Andersen, RN, and Erica Duncan, MD

Concern about the potentially diabetogenic effect of antipsychotics has existed since the introduction of chlorpromazine in the 1950s. However, there is controversy as to whether the newer “atypical” antipsychotics are more diabetogenic than older “typical”...

Pages 99-115 Read Article

GENERAL PSYCHOPHARMACOLOGY

Effects of Tranylcypromine on the Sleep of Patients with Anergic Bipolar Depression

Ripu D. Jindal, MD, Amy L. Fasiczka, MA, Jonathan M. Himmelhoch, MD, Alan G. Mallinger, MD, and Michael E. Thase, MD

A significant proportion of patients with bipolar disorder are hypersomnolent. It is not clear if this affects response to treatment because few studies have systematically examined treatment effects on sleep in patients with bipolar depression....

Pages 118-124 Read Article

GENERAL PSYCHOPHARMACOLOGY

A Preliminary Open-Label Study of Moclobemide Treatment of Pain Disorder

Ripu D. Jindal, MD, Amy L. Fasiczka, MA, Jonathan M. Himmelhoch, MD, Alan G. Mallinger, MD, and Michael E. Thase, MD

Antidepressants appear to be useful in the treatment of pain disorders, although the exact underlying mechanisms are unknown. In this preliminary study, we examined the utility of moclobemide, a reversible inhibitor of monoamine oxidase, in...

Pages 127-132 Read Article

GENERAL PSYCHOPHARMACOLOGY

Can Physiologic Assessment and Side Effects Tease Out Differences in PTSD Trials? A Double-Blind Comparison of Citalopram, Sertraline, and Placebo

Phebe Tucker, MD, Robin Potter-Kimball, RN, MS, Dorothy B. Wyatt, RN, Don E. Parker, PhD, Christie Burgin, PhD, Dan E. Jones, PhD, and Barbara K. Masters, MD

Effects of double-blind treatment of chronic posttraumatic stress disorder (PTSD) with two SSRIs and placebo on emotional symptoms and autonomic reactivity were assessed prospectively. PTSD subjects received citalopram (n=25), sertraline (n=23), or placebo (n=10) for...

Pages 135-149 Read Article