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Psychopharmacology Bulletin › All Volumes & Issues › VOL 37 No. 1
PSYCHOPHARMACOLOGY BULLETIN

VOL 37 No. 1

Articles in This Issue

DRUG DISPOSITION & PHARMACOKINETICS

Pharmacokinetics and Drug Interactions of the Sedative Hypnotics

Jun-Sheng Wang, MD, PhD, and C. Lindsay DeVane, PharmD
Sleep complaints are common among patients and may be associated with mild to severe clinical symptoms. The use of hypnotic agents to improve the onset and quality of sleep has a history dating back centuries....
Pages 10-29 Read Article
EVIDENCE-BASED MEDICINE

Evidence for the Treatment of Borderline Personality Disorder

Jane P. Gagliardi, MD, and Ranga R. Krishnan, MD
The treatment of patients with borderline personality disorder (BPD) is notoriously difficult. Psychotherapeutic and pharmacological strategies have been investigated, and a few have shown promise. Dialectical behavior therapy (DBT) may be helpful in decreasing suicidal...
Pages 30-46 Read Article
GENERAL PSYCHOPHARMACOLOGY

Does Isotretinoin Cause Depression and Suicide?

J. Douglas Bremner, MD
Isotretinoin is a retinoid approved for the treatment of cystic acne. There has been growing interest in the possible relationship between isotretinoin use and increased risk of depression and suicide. The issue, however, remains controversial....
Pages 34-78 Read Article
TRANSLATIONAL NEUROSCIENCE

New Approaches to Modeling Bipolar Disorder

Haim Einat, PhD, Robert H. Belmaker, MD, and Husseini K. Manji, MD
Modeling in animals is an invaluable tool in exploring the pathophysiology of human diseases and developing better therapies. Models can be generated using a variety of pharmacological, behavioral, and genetic approaches, but they all require...
Pages 47-63 Read Article
GENERAL PSYCHOPHARMACOLOGY

An Intent-to-Treat Method for Enhancing Analysis of Clinical Trials with Rescue Medication: A Mixed-Model Approach

Patricia R. Houck, MSH, Sati Mazumdar, PhD, Benoit H. Mulsant, MD, Bruce G. Pollock, MD, PhD, Mary Amanda Dew, PhD, and Charles F. Reynolds III, MD
An intent-to-treat (IT) analysis includes all observed data, even those obtained after the primary treatment assignment is changed or rescue treatment is substituted. The so-called “pragmatic” approach accounts for this type of treatment change or...
Pages 79-89 Read Article
GENERAL PSYCHOPHARMACOLOGY

Smoking Abstinence Impairs Time Estimation Accuracy in Cigarette Smokers

Laura Cousino Klein, PhD, Elizabeth J. Corwin, PhD, and Michele M. Stine, MEd
Time estimation is used as an index of attention processes and may be sensitive to self-administration and withdrawal of psychoactive drugs such as nicotine, the primary addictive ingredient in tobacco. To test this hypothesis, 22...
Pages 90-95 Read Article
GENERAL PSYCHOPHARMACOLOGY

Overview of the Safety of Citalopram

Charles B. Nemeroff, MD, PhD
Citalopram is a highly selective serotonin reuptake inhibitor (SSRI) that has been prescribed to over 30 million patients in more than 70 countries. The purpose of this focused overview is to summarize the data from...
Pages 93-121 Read Article