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Psychopharmacology Bulletin All Volumes & Issues VOL 36 No. 4
PSYCHOPHARMACOLOGY BULLETIN

VOL 36 No. 4

Articles in This Issue

CASE HISTORIES

Treatment of Thyrotoxicosis-Induced Psychosis

Patients with acute psychosis are generally evaluated and managed by psychiatrists. Medical evaluation to rule out underlying causes of psychosis is an important part of the initial assessment. Thyrotoxicosis, a serious medical condition requiring medical...
DRUG DISPOSITION & PHARMACOKINETICS

The Relationship of an Anticholinergic Rating Scale With Serum Anticholinergic Activity in Elderly Nursing Home Residents

The purpose of this study was to use serum anticholinergic activity (SAA) to assess the validity of a modified version of the Clinician-Rated Anticholinergic Scale (CR-ACh-mod) in evaluating anticholinergic medication exposure. The CR-ACh-mod scale assigns...
EVIDENCE-BASED MEDICINE

Practical Evidence-Based Medicine

Evidence-based medicine, the practice of making decisions about individual patient care using the best current evidence, is important for improvement of medical care. However, successfully implementing evidence-based medicine is difficult and complicated; only 15% of...
EVIDENCE-BASED MEDICINE

Evidence-Based Mental Health

Three elements exist for the practice of evidence-based mental health: development of a question, evaluation consisting of search and appraisal of the applicable literature, and synthesis of the information in the context of an individual...
TRANSLATIONAL NEUROSCIENCE

Modulators of the Glutamatergic System: Implications for the Development of Improved Therapeutics in Mood Disorders

Mood disorders have traditionally been conceptualized as neurochemical disorders, but there is now evidence from a variety of sources demonstrating regional reductions in central nervous system volume as well as reductions in the numbers and/or...
GENERAL PSYCHOPHARMACOLOGY

Survival Models With Time-Varying Coefficients: A Flexible Approach to the Analysis of Psychiatric Survival Data

Survival data from psychiatric studies are typically modeled using the Cox proportional hazards model. While the Cox model tends to provide “average” effects of covariates, these effects on the hazard may vary with time. We...
GENERAL PSYCHOPHARMACOLOGY

Duloxetine for the Treatment of Major Depressive Disorder

Background. Existing therapies for depression frequently fail to provide full remission. This report evaluates the efficacy and safety of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, in the treatment of major depressive disorder...
GENERAL PSYCHOPHARMACOLOGY

Management of Bipolar Disease in Children and Adolescents

Bipolar disorder is a serious condition that adversely affects social, emotional, academic, and family functioning in children and adolescents with the disorder. Despite the severity of this illness, there is very little data to guide...