VOL 36 No. 4

It is both an honor and a challenge to assume the helm as editor of Psychopharmacology Bulletin. The honor, of course, is that a lifelong bibliophile and unabashed lover of the written word has the...

Patients with acute psychosis are generally evaluated and managed by psychiatrists. Medical evaluation to rule out underlying causes of psychosis is an important part of the initial assessment. Thyrotoxicosis, a serious medical condition requiring medical...

The purpose of this study was to use serum anticholinergic activity (SAA) to assess the validity of a modified version of the Clinician-Rated Anticholinergic Scale (CR-ACh-mod) in evaluating anticholinergic medication exposure. The CR-ACh-mod scale assigns...

Evidence-based medicine, the practice of making decisions about individual patient care using the best current evidence, is important for improvement of medical care. However, successfully implementing evidence-based medicine is difficult and complicated; only 15% of...

Three elements exist for the practice of evidence-based mental health: development of a question, evaluation consisting of search and appraisal of the applicable literature, and synthesis of the information in the context of an individual...

Mood disorders have traditionally been conceptualized as neurochemical disorders, but there is now evidence from a variety of sources demonstrating regional reductions in central nervous system volume as well as reductions in the numbers and/or...

Survival data from psychiatric studies are typically modeled using the Cox proportional hazards model. While the Cox model tends to provide “average” effects of covariates, these effects on the hazard may vary with time. We...

Understanding the neurochemistry of schizophrenia involves the study not only of neurotransmitters and their receptors, but also of the signal transduction systems that translate their actions into neural activity. Of particular interest is the signal...

Background. Existing therapies for depression frequently fail to provide full remission. This report evaluates the efficacy and safety of duloxetine, a dual reuptake inhibitor of serotonin and norepinephrine, in the treatment of major depressive disorder...

This review presents the pharmacology of antidepressants as it relates to their effects on several neurotransmitters and their receptors. A theory about the mechanism of action of these drugs is presented, along with data for...

Bipolar disorder is a serious condition that adversely affects social, emotional, academic, and family functioning in children and adolescents with the disorder. Despite the severity of this illness, there is very little data to guide...