VOL 35 No. 3

TRANSLATIONAL NEUROSCIENCE

Inositol, Lithium, and the Brain

Bernard W. Agranoff, MD, and Stephen K. Fisher, PhD

This review of the background and present state of knowledge of the interactions of inositol metabolism and lithium commemorates the 150th anniversaries of the discovery of inositol and, independently, of first attempts to use lithium...

Pages 5-18 Read Article

DRUG INTERACTIONS

Therapeutic Drug Monitoring of Antipsychotics

Paul J. Perry, PhD

Therapeutic drug monitoring of conventional and atypical antipsychotics offers numerous clinical advantages to the clinician. These include cost savings, decreased risk of toxicity, and improved compliance. Among these drugs, studies of haloperidol, olanzapine, and clozapine...

Pages 19-28 Read Article

DRUG INTERACTIONS

A Primer on Caffeine Pharmacology and Its Drug Interactions in Clinical Psychopharmacology

Jennifer L. Donovan, PhD, and C. Lindsay DeVane, PharmD

Caffeine in the form of various beverages and as an additive in numerous drug formulations is the most widely consumed drug in the world. Its psychostimulant properties account for much of its popularity. Caffeine has...

Pages 30-46 Read Article

COMPLICATED CASE HISTORIES

Neuroleptic Malignant Syndrome Due to Olanzapine

Karen L. Hall, MD, William H. Taylor, MD, and Michael R. Ware, MD

Neuroleptic malignant syndrome (NMS) is a rare and potentially fatal complication precipitated by the use of antipsychotic medications, most notably haloperidol. Criteria previously described include: exposure to the neuroleptic class of medications; hyperthermia; muscle rigidity;...

Pages 49-55 Read Article

BRAIN IMAGING

Gender Differences in Cognitive and Neural Correlates of Remembrance of Emotional Words

J. Douglas Bremner, MD, Robert Soufer, MD, Gregory McCarthy, PhD, Richard Delaney, PhD, Lawrence H. Staib, PhD, James S. Duncan, PhD, and Dennis S. Charney, MD

Studies suggest that men and women have important differences in specific cognitive functions. Men show superior spatial memory and women demonstrate superior verbal memory, and women rely on emotional content to a greater degree in...

Pages 55-78 Read Article

GENERAL PSYCHOPHARMACOLOGY

Informant-Rated Cognitive Symptoms in Normal Aging, Mild Cognitive Impairment, and Dementia

K. Ranga R. Krishnan, MD, Robert M. Levy, BS, H. Ryan Wagner, PhD, Gene Chen, BS, Kenneth Gersing, MD, and P. Murali Doraiswamy, MD

An informant-rated cognitive screen may have the potential to reliably help detect early dementia. A valuable scale should have good interitem associations and strong reliability when tested in groups with and without cognitive impairment. Our...

Pages 79-88 Read Article

GENERAL PSYCHOPHARMACOLOGY

Sexual Side Effects Associated With Conventional and Atypical Antipsychotics

Michael T. Compton, MD, and Andrew H. Miller, MD

The sexual side effects of psychotropic medications are becoming increasingly recognized in clinical psychiatry. The magnitude of the problem of sexual side effects associated with antipsychotic medications has yet to be fully elucidated, but a...

Pages 89-108 Read Article

GENERAL PSYCHOPHARMACOLOGY

An Evidence-Based Review of Psychosocial Treatments for Bipolar Disorder

Mark S. Bauer, MD

Because somatotherapy for bipolar disorder (BD) has led to only modest improvements in outcome in general clinical practice, increasing attention has been paid to psychosocial interventions as adjuvants to standard medical-model treatment. This article complements...

Pages 109-134 Read Article

GENERAL PSYCHOPHARMACOLOGY

Premenstrual Exacerbations of Mood Disorders

Merry N. Miller, MD, and Barney E. Miller, PhD

Premenstrual exacerbation of mood disorders has received little attention, despite the recent interest in premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS). Differentiating between PMDD/PMS and other disorders, which worsen premenstrually, is a poorly understood...

Pages 135-149 Read Article

GENERAL PSYCHOPHARMACOLOGY: SURV E Y

A Survey of Prescribing Preferences in the Treatment of Refractory Depression: Recent Trends

Rebecca Kornbluh, MD, George I. Papakostas, MD, Timothy Petersen, PhD, Nicole B. Neault, BA, Andrew A. Nierenberg, MD, Jerrold F. Rosenbaum, MD, and Maurizio Fava, MD

The objective of this study was to gather data from a large group of clinicians on antidepressant prescribing practices in the treatment of refractory depression. Eight hundred and thirty-five clinicians about to attend the annual...

Pages 136-150 Read Article