VOL 35 No. 1 Archives - MedWorks Media

EDITOR’S LETTER

EDITOR’S LETTER: Charles B. Nemeroff, MD, PhD

Charles B. Nemeroff, MD, PhD

Welcome! Or should I say welcome back! Many of you remember Psychopharmacology Bulletin when it was a United States government publication which contained topical reviews and expanded abstracts of annual research meetings, such as the...

Pages 5-5 Read Article

TRANSLATIONAL NEUROSCIENCE

Corticosteroid Receptors: A Dynamic Interplay Between Protein Folding and Homeostatic Control

Claudio A. Caamaño, PhD, M. Inés Morano, PhD, and Huda Akil, PhD

Glucocorticoids are key elements in the maintenance of an organism’s homeostasis, a dynamic balance that is constantly challenged by internal and external stressors. Chronic exposure to elevated glucocorticoids may induce profound effects on an individual’s...

Pages 6-23 Read Article

TRANSLATIONAL NEUROSCIENCE

Nitric Oxide, Stress, and Depression

Tyler M. McLeod, BS, Antonio L. López-Figueroa, MD, and Manuel O. López-Figueroa, PhD

Stress and depression have a significant impact on modern society. Even though their symptomatology is well characterized, little is known about the molecular mechanisms underlying these disturbing disorders. While the role of neurotransmitters such as...

Pages 24-41 Read Article

DRUG INTERACTIONS

An Explanation of the Second-Dose Effect in Pharmacokinetics and Its Meaning for Clinical Psychopharmacology

C. Lindsay DeVane, PharmD, and Heidi L. Liston, PharmD

Most psychopharmacologic agents are administered in multiple dosing regimens. Frequently, the relative intensity and/or duration of action of a second dose of medication appear to differ from the initial dose. A theoretical pharmacokinetic basis exists...

Pages 42-52 Read Article

DRUG INTERACTIONS

The Emerging Recognition of Herb-Drug Interactions With a Focus on St. John’s Wort (Hypericum Perforatum)

John S. Markowitz, PharmD, and C. Lindsay DeVane, PharmD

The use of herbal medications and other alternative therapies is accelerating. Survey data clearly indicate that these agents are frequently combined with prescription and over-the-counter medications. The herbal antidepressant St. John’s wort (Hypericum perforatum) is...

Pages 53-64 Read Article

COMPLICATED CASE HISTORIES

Generalized Anxiety Disorder: Diagnosis, Neurobiology, and Treatment

Philip T. Ninan, MD

LJ is a 47-year-old divorced male who presented with a chief complaint of anxiety. He described anxiety as being nervous and not being able to turn his mind off. He was worrying uncontrollably about his...

Pages 65-76 Read Article

COMPLICATED CASE HISTORIES

Comorbid Obsessive Compulsive and Major Depressive Disorder

Philip T. Ninan, MD

PM is a 43-year-old married female referred by her primary care physician for a psychiatric consultation because of a failure to improve on fluvoxamine. She reported intrusive ideas including fears of contamination, a need for...

Pages 77-83 Read Article

BRAIN IMAGING

Imaging the Roles of the Amygdala in Drug Addiction

Clinton D. Kilts, PhD

The neurobiological processes that underlie initial use of drugs of abuse and the transition to drug abuse, addiction, and dependence are poorly understood. Intrinsic and drug-related alterations in complex brain functions such as motivation, learning,...

Pages 84-94 Read Article

BRAIN IMAGING

Neurodevelopmental Models of Schizophrenia: Pathophysiologic Synthesis and Directions for Intervention Research

Todd Lencz, PhD, Barbara Cornblatt, PhD, and Robert M. Bilder, PhD

This paper examines contemporary models of the pathophysiology of schizophrenia from a neurodevelopmental perspective. Specifically, this article reviews recent research in the neuropathology, neuroimaging, and developmental psychopathology of schizophrenia, with an aim to critically evaluate...

Pages 95-125 Read Article

VOL 35 No. 1

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