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RESEARCH ARCHIVE

Research Articles

Articles related to: Alzheimer’s, alzheimer’s disease, Alzheimer’s Disease Assessment Scale (ADAS)

Research Articles

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Alzheimer’s alzheimer’s disease Alzheimer’s Disease Assessment Scale (ADAS)
REVIEW ARTICLE

Psychopharmacotherapy of Alzheimer’s Disease—What Do We Have at Hand?

Ahmed Naguy, Saxby Pridmore, Anubhuti Singh, Awadhesh Solanki
~ Alzheimer’s disease (AD) is a devastating relentlessly progressive illness for which currently there is no definitive curative treatment. The mainstay of treatment remains symptomatic, though. Psychopharmacotherapy is only part of a multi-pronged package of...
Psychopharmacology Bulletin 56(2): 170-175, 2026/03/11
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REVIEW ARTICLE

Pharmacotherapy of Neuropsychiatric Syndromes in Neurologic Disorders: Definitional and Regulatory Aspects

Jeffrey L. Cummings, MD and Dilip V. Jeste, MD
Background: Neuropsychiatric symptoms are common in many neurologic diseases. Psychosis, depression, agitation, anxiety, irritability, and apathy occur in degenerative, traumatic, vascular, and demyelinating brain diseases. Design: Regulatory policies regarding approval of psychotropic agents for treatment...
Psychopharmacology Bulletin 40(4): 89-98, 2008/01/25
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REVIEW ARTICLE

Genetics and Its Use in Alzheimer’s Disease

Joseph H. Lee, DRPH and Richard Mayeux, MD, MSC
How useful is genetics to a clinician who treats patients with Alzheimer’s disease (AD)? Even though much has been learned about the genetics of AD, given the current state of knowledge, the application of genetics...
Psychopharmacology Bulletin 40(4): 132-144, 2007/08/15
Pages 132-144 Read Article
BRAIN IMAGING

Applications of Neuroreceptor Imaging to Psychiatry Research

Gwenn S. Smith, PhD, Jeremy Koppel, MD, and Sara Goldberg, BA
Over the past two decades, there have been significant advances in the ability to study the neurochemistry of the living brain using neuroreceptor radiotracers with Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography...
Psychopharmacology Bulletin 37(4): 26-56, 2004/02/27
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Valproate Use in Neuropsychiatric Disorders in the Elderly

Pierre N. Tariot, MD
The literature regarding the use of valproate in the elderly derives primarily from studies in patients with dementia who experience agitation. At this juncture, there are 5 case reports or case series in patients with...
Psychopharmacology Bulletin 37(Suppl. 2): 116-128, 2003/07/15
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GENERAL PSYCHOPHARMACOLOGY

Therapeutic Implications of HPA Axis Abnormalities in Alzheimer’s Disease: Review and Update

Nunzio Pomara, MD, William M. Greenberg, MD, Michael D. Branford, and P. Murali Doraiswamy, MD
The adaptive and maladaptive roles of the hypothalamic-pituitary-adrenal (HPA) axis in stressful conditions and in disorders such as major depression, posttraumatic stress disorder, and Cushing’s syndrome have been the subject of substantial ongoing study. In...
Psychopharmacology Bulletin 37(2): 120-134, 2003/04/15
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DRUG DISPOSITION & PHARMACOKINETICS

Alzheimer’s Disease and the Glutamate NMDA Receptor

P. Murali Doraiswamy, MD
Current treatment of Alzheimer’s disease (AD) has focused on the use of cholinesterase inhibitors. This review emphasizes emerging therapies for the treatment and/or prevention of AD, with a focus on glutamatergic excitotoxicity in dementia and...
Psychopharmacology Bulletin 37(2): 41-47, 2003/01/15
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GENERAL PSYCHOPHARMACOLOGY

Informant-Rated Cognitive Symptoms in Normal Aging, Mild Cognitive Impairment, and Dementia

K. Ranga R. Krishnan, MD, Robert M. Levy, BS, H. Ryan Wagner, PhD, Gene Chen, BS, Kenneth Gersing, MD, and P. Murali Doraiswamy, MD
An informant-rated cognitive screen may have the potential to reliably help detect early dementia. A valuable scale should have good interitem associations and strong reliability when tested in groups with and without cognitive impairment. Our...
Psychopharmacology Bulletin 35(3): 79-88, 2001/07/15
Pages 79-88 Read Article
GENERAL PSYCHOPHARMACOLOGY

Clinical Trials in Alzheimer’s Disease

Thomas E. Gillen, MD, MS; Keith M. Gregg, PhD; Huixing Yuan, PhD; Matthias C. Kurth, MD, PhD; and K. Ranga Krishnan, MB, ChB
The database of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) is a seminal work in the field of cognitive dysfunction and Alzheimer’s disease. This 24-center study of 1,094 patients with Alzheimer’s disease...
Psychopharmacology Bulletin 35(2): 83-96, 2001/04/15
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