Ziprasidone Induced Tardive Cervical Dystonia

Fifty years old female patient used 80 mg/day ziprasidone for 4 months after diagnosed as atypical depression. After 4 months of ziprasidone treatment, involuntary movements appeared in her neck region. Ziprasidone was stopped in by tapering 20 mg/day, but the involuntary movements continued and even exacerbated. Then, oral clonazepam treatment was started but no improvement was observed. Finally, she was administered Botulinum Toxin A (BTX-A) treatment. After the fourth BTX-A injection therapy, significant reduction in neck pain and improvement of head deviation was observed. Psychopharmacology Bulletin. 2009;42(4):64–68.