Polypharmacy and EPS in a Child; A Case Report

Aysegul Yolga Tahiroglu, MD and Ayse Avci, MD

Psychopharmacology Bulletin 40(2) :129-133 , 2007/05/07

Abstract

Extrapyramidal symptoms (EPSs) (dystonic reaction, rigidity, and akathisia) occur as a result of D2 receptor blockade. Selective serotonin-reuptake inhibitors (SSRIs) have been reported to induce extrapyramidal signs and symptoms but tricyclic antidepressants have been rarely reported. Among the side effects attributed to valproic acid administration, the production of EPS is very rare, particularly in children. In this paper we present a case (10-year-old girl) under multiple pharmacologic treatment who developed EPSs (oculogyric crisis) shortly after the adjunct of imipramine to a combination of methylphenidate and valproic acid. Oculogyric crisis occurred on the third day of this combination treatment and these symptoms included ocular pain and sustained upward gaze. Benztropine 2 mg i.m. resulted in rapid relief of oculogyric crisis symptoms. Psychopharmacology Bulletin. 2007;40(2):129-133.

Keywords

antidepressant, antiepileptic, child, extrapyramidal symptom (EPS), stimulant

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How to Cite

Aysegul Yolga Tahiroglu, MD and Ayse Avci, MD. Polypharmacy and EPS in a Child; A Case Report. Psychopharmacology Bulletin. 2007/05/07; 40(2):129-133.