Abstract
Background
Chronic pain is a prevalent and debilitating problem for millions of people and spinal cord stimulation (SCS) is one option for treatment. It has been shown to have membrane stabilizing properties and is often used in conjunction with medications that are also believed to offer pain control through membrane stabilization.
Objective
The goal of this review is to analyze the effects of SCS combined with medications to evaluate for augmentative therapeutic effect.
Setting
Systematic review.
Methods
A systematic computerized search of the literature was conducted using PubMed, the Cochrane Library, and EMBASE for articles published in English.
Results
We report three articles that discuss the potential for augmentative effects of medication in combination with SCS. Located articles related primarily to SCS combined with Gabapentin, TCA, or SNRI.
Limitations
The limited number of articles reflects a need for more investigation in this area.
Conclusion
Based on the suspected mechanisms for SCS and neuromodulating medications, there is reason to believe adding these medical therapies may enhance the effects of SCS.
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