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Psychopharmacology Bulletin › All Volumes & Issues › VOL 37 No. 2 › DDTC, a Metabolite...
GENERAL PSYCHOPHARMACOLOGY

DDTC, a Metabolite of Disulfiram, Reduces the Stimulating Effect on Ethanol’s Locomotor Activity in Mice

Maria Dolores Escarabajal, PhD, and Carlos M.G. Aragon, PhD
Psychopharmacology Bulletin 37(2): 113-117, 2003/04/15; https://doi.org/10.64719/pb.4189

Abstract

To investigate how diethyldithiocarbamate (DDTC) affects the stimulating effect of ethanol on open-field locomotion, mice were pretreated with different doses of DDTC 8 hours prior to ethanol. The effect of DDTC and saline on different ethanol doses was analyzed. DDTC reduces ethanol-induced locomotor activity in a dose-dependent manner, but does not affect spontaneous locomotor activity. Aldehyde dehydrogenase might influence the psychopharmacological effects of ethanol. Psychopharmacology Bulletin. 2003;37(2):113-119

Keywords

acetaldehyde, diethyldithiocarbamate (DDTC), disulfiram, ethanol, locomotor activity, mice

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How to Cite

Maria Dolores Escarabajal, PhD, and Carlos M.G. Aragon, PhD. DDTC, a Metabolite of Disulfiram, Reduces the Stimulating Effect on Ethanol’s Locomotor Activity in Mice. Psychopharmacology Bulletin. 2003/04/15; 37(2):113-117. https://doi.org/10.64719/pb.4189