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Psychopharmacology Bulletin › All Volumes & Issues › VOL 52 No. 3 › Correlation of 1846G>A...
DRUG DISPOSITION & PHARMACOKINETICS

Correlation of 1846G>A Polymorphism of CYP2D6 Gene with Haloperidol Efficacy and Safety in Patients with Alcoholic Hallucinoses

AA Parkhomenko, MS Zastrozhin, VYu Skryabin, VA Ivanchenko, SA Pozdniakov, VV Noskov, IA Zaytsev, NP Denisenko, KA Akmalova, EA Bryun, DA Sychev
Psychopharmacology Bulletin 52(3) :58-67

Abstract

Previous studies have shown that haloperidol biotransformation occurs with participation of the CYP2D6 isoenzyme. The CYP2D6 gene is highly polymorphic, which may contribute to differences in its activity and in the haloperidol biotransformation rates across different individuals, resulting in variable drug efficacy and safety profiles.

Keywords

alcoholic hallucinosis, CYP2D6, haloperidol, personalized medicine, pharmacogenetics

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How to Cite

AA Parkhomenko, MS Zastrozhin, VYu Skryabin, VA Ivanchenko, SA Pozdniakov, VV Noskov, IA Zaytsev, NP Denisenko, KA Akmalova, EA Bryun, DA Sychev. Correlation of 1846G>A Polymorphism of CYP2D6 Gene with Haloperidol Efficacy and Safety in Patients with Alcoholic Hallucinoses. Psychopharmacology Bulletin. 52(3):58-67.