Can Physiologic Assessment and Side Effects Tease Out Differences in PTSD Trials? A Double-Blind Comparison of Citalopram, Sertraline, and Placebo

Effects of double-blind treatment of chronic posttraumatic stress disorder (PTSD) with two SSRIs and placebo on emotional symptoms and autonomic reactivity were assessed prospectively. PTSD subjects received citalopram (n=25), sertraline (n=23), or placebo (n=10) for 10 weeks, with psychophysiologic assessments performed before and after treatment. Intent-to-treat analysis showed that all treatment groups improved significantly in total PTSD symptoms (as measured by the Clinician-Administered PTSD Scale), all three PTSD symptom clusters, and sleep time. However, subtle differences in improvements in PTSD symptom clusters, physiologic reactivity, and reported adverse events were identified. Citalopram-treated subjects significantly lowered systolic and diastolic blood pressures, while sertraline- and placebo-treated patients significantly lowered only systolic blood pressure reactivity to individualized trauma scripts. The sertraline group showed significantly more improvement in avoidance/numbing symptoms than both other groups. Considering side effects, subjects on sertraline reported more gastrointestinal problems, with early terminators having more insomnia. Early terminators on citalopram reported more fatigue and appetite changes than other treatment groups, with completers reporting more sexual dysfunction.