Amisulpride for Clozapine Induced Sialorrhea

Clozapine is an atypical and novel antipsychotic medication useful for patients with schizophrenia who are refractory to treatment. Its use is often associated with troublesome side effects like sialorrhea, sedation, weight gain, enuresis, dizziness, besides life threatening side effects like agranulocytosis. Drug treatments used for Clozapine induced sialorrhea (CIS) like anticholinergic drugs and alpha 2 receptor antagonists have their own added side effects. A case of CIS responding to low dose of Amisulpride is reported. Psychopharmacology Bulletin. 2009;42(4):69–71.