News, research, and clinical insights on depression, major depressive disorder, and mood disorders — including treatment, antidepressants, and perinatal mood conditions.
Salt Lake City, UT — Lipocine Inc. announced positive progress in its pivotal phase 3 clinical trial evaluating oral brexanolone (LPCN 1154) for the treatment of postpartum depression…
Recent changes in the legal landscape in the United States have affected access to abortion, and this restricted access has profound effects on both physical and mental health…
Two new studies examining mental health risks postpartum were published online in the American Journal of Psychiatry in conjunction with Maternal Mental Health Awareness Month and the 2025…
Objective Postpartum depression (PPD), now referred to as perinatal depression, is a prevalent and debilitating mood disorder that reduces health-related quality of life (HRQoL) and psychosocial functioning. Esketamine,…
Background In VIVRE (NCT04448431), vortioxetine was associated with significantly higher rates of symptomatic and functional remission, better daily and social functioning, and greater treatment satisfaction than desvenlafaxine in…
According to a brief on Medscape, supported by the NIH, The use of general anesthesia during cesarean deliveries is associated with an increased risk for postpartum depression (PPD)…
Salt is found in nearly every kitchen across the world; however, it is not typically thought of to be a means for suicide. Depending on the age and…
According to published reports, The US Food and Drug Administration (FDA) has granted Breakthrough Device designation to Sooma Medical’s portable, noninvasive neuromodulation device for treating depression, which can…
Objective: To compare the efficacy and speed of achieving remission/response in treatment-resistant depression (TRD) patients treated with subanesthetic intravenous (IV) ketamine and intranasal (IN) esketamine approved by the…
Whereas symptoms of depression are known to intensify in patients who have recently experienced an incident stroke, it might also be true in such cases that the depression actually starts to…
Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as…
The antidepressant fluvoxamine (Luvox) may prevent hospitalization and death in outpatients with COVID-19, new research suggests. Results from the placebo-controlled, multisite, phase 3 TOGETHER trial showed that in COVID-19 outpatients…
SUMMARY In this study, we observed that compared to women with no prior cancer, breast cancer survivors had higher risk of anxiety, depression, sleep problems, sexual dysfunction, fatigue,…
In a recent study, researchers described treatment-emergent sexual dysfunction (TESD) and tolerability following a switch from selective serotonin reuptake inhibitor (SSRI: citalopram, paroxetine, or sertraline) monotherapy to vortioxetine…
Although currently available antidepressants increase monoamine levels soon after the start of treatment, therapeutic benefits are often delayed by several weeks and the majority of patients with major…
The US Food and Drug Administration (FDA) has approved brexanolone intravenous infusion (Zulresso, Sage Therapeutics), the first-ever drug indicated for the treatment of postpartum depression. The drug is administered…
The Food and Drug Administration yesterday approved an intranasal form of esketamine for treatment-resistant depression in adults who have failed at least two oral antidepressants of different classes. The…
By Lara Bücker , Julia Bierbrodt, Iver Hand, Charlotte Wittekind, and Steffen Moritz Background Problematic and pathological gambling have been linked to depression. Despite a high demand for treatment and negative financial…
In 2006, psychiatrist Carlos A. Zarate Jr, MD, and colleagues at the National Institute of Mental Health (NIMH) published a seminal finding in Archives of General Psychiatry (now…
On individuals with major depressive disorder (MDD), particularly those who experience suicidal thinking, levels of translocator protein (TSPO), a marker of microglial inflammation, are increased, new research shows.…
This work was sponsored by a Young Investigator Grant from the American Foundation for Suicide Prevention (AFSP) BACKGROUND Suicide is preventable, yet still remains a worldwide cause of…
By Maria R. Restivo , Margaret C. McKinnon, Benicio N. Frey, Geoffrey B. Hall, Wasimuddin Syed, Valerie H. Taylor In a research article published in the Open Access…
The Achilles Heel of psychiatry has always been the public’s distrust of what defines a mental disorder and whether it can be treated effectively. Oftentimes, not until a…
Giving severely depressed patients the arthritis drug celecoxib (brand name Celebrex) dramatically boosted the effectiveness of their antidepressant medication, according to new research. Patients were randomly assigned to…
Other than the obvious onset of the mental disorder itself, postpartum depression is one of those illnesses that is hard to predict, and according to published records, may…
By Alexander C. Tsai, Mark Tomlinson, W. Scott Comulada, and Mary Jane Rotheram-Borus Abstract Background Violence against women by intimate partners remains unacceptably common worldwide. The evidence base for the…
